● fiAction● Contraindications and PrecautionsContraindicated in:● • Children (safety not established) • Concomitant (or within 14 days) use with MAOIs • Severe renal or hepatic impairment • Pregnancy and lactation (safety not established) • Uncon-trolled narrow-angle glaucomaUse Cautiously in:● ● tory of drug abuse • Patients with suicidal ideation • Patients ● history of mania • Patients with history of seizures • Children Adverse Reactions and Side Effects ● ● with history of or existing cardiovascular disease • Patients with ● ● ciency • Elderly and debilitated patients • Patients with his-Dizziness SNRIs are potent inhibitors of neuronal serotonin and nor-Dry mouth epinephrine reuptake; weak inhibitors of dopamine reuptake. Nausea AstheniaSomnolence DiarrheaHeadache ConstipationInsomnia • Patients with hepatic and renal insuf- • Hypersensitivity to the drug Antidepressants ●^431
2 2506_Ch26_417-446.indd 1431 506 Ch 26 417 - 446 .indd ● 1 ● ● ● Interactions● ● ● 43 symptoms for which the medication was prescribed. A gradual Increased effects of venlafaxine with box warning)Increased risk of suicidality in children and adolescents (black antifungalsDiscontinuation syndrome. Abrupt withdrawal may result in Increased effects of symptoms such as nausea, vomiting, nervousness, dizziness, Mydriasis (venlafaxine)trazodoneheadache, insomnia, nightmares, paresthesias, and a return of minereduction in dosage is recommended. Concomitant use with fatal, effects resembling neuroleptic malignant syndrome. Coadministration is contraindicated.Serotonin syndrome may occur when SNRIs are used con-comitantly with 1 when used concomitantly with venlafaxine, or other drugs that increase levels of serotonin.St. John’shaloperidol, clozapine, MAOIs^ wort, sumatriptan results in serious, sometimes cimetidine , sibutramineand desipra-and azole , 1 10/1/10 9:39:22 AM 0 / 1 / 10 9 : 39 : 22 AM
