●^474 ● ● ● ● ● ● ● ● ● ● Interactions● ● ● Route and Dosage Concurrent use with phenothiazines may increase or decrease are increased.severe hypotension.Increased effects of phenothiazines with Concurrent use with Coadministration of phenothiazines and Concurrent administration with Increased hypotension with depressantsexcessive sedation and hypotension.Increased CNS depression with Therapeutic effects of phenothiazines may be decreased by centrally acting anticholinergics. Increased orthostatic hypotension with Tardive dyskinesia phenytoinConcurrent use may result in decreased hypotensive effect of guanethidine.Prolongation of QT interval (Phenothiazines may reduce effectiveness of increase effects from either or both drugs.ulants.Neuroleptic malignant syndrome^ ●^ PSYCHOTROPIC MEDICATIONS levels. epinephrineantihypertensivesthioridazine or meperidinealcoholdopamineAnticholinergic effects thiazide diureticsparoxetinebeta-blockers) or other oral anticoag- may produce may result in CNS may
2 2506_Ch28_472-501.indd 1474 506 Ch 28 472 - 501 .ind IMNausea and Vomiting:Psychotic Disorders:Pediatric Behavioral Disorders:CHLORPROMAZINEChildren >6 months: Intractable Hiccoughs:d 25 mg 2 or 3 times a day. Increase by 20 to 50 mg every 3 to 4 days until effective dose is reached, usually 200 to 400 mg/day. IM:in 1 hour. Increase gradually over several days (up to 400 mg children up to 5 years or 75 mg/day in children 5 to 12 years). every 4 to 6 hours in severe cases). 3 to 4 hours. POin children 6 months to 5 years or 75 mg/day in children 6 to 6 hours. daily. If symptoms persist for 2 to 3 days, give 25 to 50 mg 12 years). 1474 : 0.5 mg/kg every 6 to 8 hours (not to exceed 40 mg/day : 0.5 mg/kg every 4 to 6 hours as needed. 0.55 mg/kg every 6 to 8 hours (not to exceed 40 mg/day in IM: Initial dose: 25 mg. May give additional 25 to 50 mg IM: 25 mg initially, may repeat 25 to 50 mg every PO^ Adults^ : 0.55 mg/kg every 4 to 6 hours.^ Adults: Adults: PO: POPO: 10 mg 3 or 4 times a day or : 25 to 50 mg 3 or 4 times : 10 to 25 mg every 4 to^ Children >6 monthsIM. :^1 10/1/10 9:40:04 AM 0 / 1 / 10 9 : 40 : 04 AM