(^486) Route and Dosage LOXAPINESchizophrenia:CLOZAPINESchizophrenia and Recurrent Suicidal Behavior: NOTE: for possible seizures and agranulocytosis. recurrent suicidal behavior. Titrate dosage slowly to observe 6 months of treatment. Because of the risk of agranulocytosis, 600 mg/day for schizophrenia and 300 mg/day for reducing 3 divided doses. The mean and median doses are approximately once or twice weekly to a maximum dosage of 900 mg/day in day, although some severely disturbed patients may require up to 50 mg/day. Increase dosage fairly rapidly over the fiadditional increases in increments of 100 mg not more than 10 days until symptoms are controlled. The usual therapeutic and maintenance dosage range is 60 mg to 100 mg/day. Doses higher than 250 mg/day are not recommended. Dosage should be maintained at the lowest level effective for controlling symptoms. tiation of treatment with clozapine and weekly for the fito a target dose of 300 to 450 mg/day. If required, make increase dosage by 25 to 50 mg/day over a period of 2 weeks solute neutrophil count (ANC) must be taken before ini-PO^ ●: Initial dose: 12.5 mg once or 2 times a day. May^ PSYCHOTROPIC MEDICATIONS (Loxitane) (Clozaril) A baseline white blood cell (WBC) count and ab- Adults: PO: Initial dosage: 10 mg 2 times a rst 7 to Adults: rst
Agitation Associated with Schizophrenia or Mania:OLANZAPINESchizophrenia:Bipolar Disorder:clozapine is available only in a 1-week supply through the IM:May repeat in 2 hours and again 4 hours later, if needed. A MC at least 2,000/mmincrease every 24 hours by 5 mg/day (not to exceed 20 mg/day). testing, patient monitoring, and controlled distribution counts may be monitored biweekly, and a 2-week supply of medication may then be dispensed. If for a 6-month period the counts remain within the acceptable level for the biweekly period, counts may then be monitored every 4 weeks there-after. When the medication is discontinued, weekly WBC counts are continued for an additional 4 weeks. through participating pharmacies. If the counts remain with-at weekly intervals by 5 mg/day (not to exceed 20 mg/day). Clozaril Patient Management System, which combines WBC in the acceptable levels (i.e., WBC at least 3,500/mm 2.5 to 10 mg, administered slowly, deep into muscle mass.^ (Zyprexa)^ Adults:^ Adults: PO:^3 ) during the 6-month period, blood PO:5 t o 10 m g /d a y i n it i a l l y ; m a y i nc r e a s e 10 to 15 mg/day initially; may^3 and the Adults:
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