Example^490 Acute Agitation in Schizophrenia:Bipolar Mania:ZIPRASIDONESchizophrenia:● Generic (Trade) AripiprazoleName with food. May increase dosage by intervals of at least 2 days up to a dosage of 80 mg 2 times a day. (Abilify)and effi10 mg every 2 hours or 20 mg every 4 hours. as needed up to a maximum of 40 mg/day. May be given as 60 or 80 mg 2 times a day. Adjust dosage on the basis of toleration with food. On the second day of treatment, increase dose to CHEMICAL CLASS: QUINOLINONES^ ●^ PSYCHOTROPIC MEDICATIONS cacy within the range of 40 to 80 mg 2 times a day. Categories/Half-life (hr)C/75 (aripiprazole);Pregnancy^ (Geodon) 94 (metabolite)^ Adults: Adults: PO:PO: ●●Indications●● Initial dosage: 40 mg 2 times a day Initial dosage: 20 mg 2 times a day Schizophreniawith schizophrenia Major depression, adjunctive therapyAgitation associated Bipolar maniaor bipolar mania (IM)^ Adults: Inj: 7.5 mL Available Forms (mg)Oral solution: 1/mLTabs: 2, 5, 10, 15, 20, 30Tabs (orally disintegrating): 10, 15IM: 10 to 20 mg
2 2506_Ch28_472-501.indd 1490 506 Ch 28 472 - 501 .indContraindications and Precautions • Conditions that cause hypotension (dehydration, hypovole-that increase the core body temperature (excessive exercise, ex-posure to extreme heat, dehydration) • Patients with diabetes or risk factors for diabetes • Pregnancy (weigh benefi● drug to potential risk to fetus) • Children and adolescents (Actionand effectiveness not establishedmia, treatment with antihypertensive medication) • Conditions related psychosis (Contraindicated in:dUse Cautiously in:● impairment • Known cardiovascular or cerebrovascular disease combination of partial agonist activity at DThe effitors and antagonist activity at 5-HT Also exhibits antagonist activity at adrenergic 1490 cacy of aripiprazole is thought to occur through a black box warning • History of seizures • Hepatic or renal • Hypersensitivity • Lactation) • Elderly patients with dementia-2A) receptors.^2 and 5-HTα^1 receptors. ts of the 1A recep-safety 1 10/1/10 9:40:11 AM 0 / 1 / 10 9 : 40 : 11 AM
