Children and adolescents up to 70 kg:ATOMOXETINEADHD:Adjusted dosing: Coadministration with strongChildren weighing 70 kg (154 lb) or less:AdjustedRoute and Dosage daily dose of about 1.2 mg/kg taken either as a single dose in target dose of 80 mg/day if symptoms fail to improve after well tolerated. Initiate dosage at 40 mg/day and only increase to the usual (154 lb):Adults, adolescents, and children weighing more than 70 kg:symptoms fail to improve after 4 weeks and the initial dose is of 3 days to a target total daily dose of 80 mg, as a single dose in the morning or 2 evenly divided doses in the morning and late afternoon or early evening. After 2 to 4 weeks, total dosage may be increased to a maximum of 100 mg, if needed.and only increase to the usual target dose of 1.2 mg/kg/day if with severe hepatic impairment, reduce to 25% of usual dose. hepatic impairment, reduce to 50% of usual dose. In clients 4 weeks and the initial dose is well tolerated. kg/day. Increase after a minimum of 3 days to a target total or 100 mg daily, whichever is less.the morning or 2 evenly divided doses in the morning and late afternoon or early evening. Maximum daily dose: 1.4 mg/kg Agents Used to Treat Attention-Defi^ Adults, adolescents, and children weighing more than 70 kg Dosing PO: Initial dose: 40 mg/day. Increase after a minimum^ (Strattera) : Hepatic impairment: Initiate dosage at 0.5 mg/kg/day cit/Hyperactivity Disorder^ In clients with moderate PO: Initial dose: 0.5 mg/^ CYP2D6 inhibitors:●^533
2 2506_Ch31_522-537.indd 1533 506 Ch 31 522 - 537 .indd Depression (Wellbutrin):ADHD: 1 Sustained release tabs: BUPROPIONAdults: 53 tabs):prevent the risk of seizures, administer with 4 to 6 hours No single dose of bupropion should exceed 150 mg. To an increase in dosage up to 450 mg/day may be considered. improvement after several weeks of dosing at 300 mg/day, 100 mg given 3 times/day. For patients who do not show 3 divided doses. ing. May increase to twice a day (total 300 mg), with 8 hours exceed 150 mg. To prevent the risk of seizures, administer between doses. with 4 to 6 hours between doses. between doses.day. May titrate to a maximum dose of 6 mg/kg/day. Single dose should not exceed 150 mg. Usually given daily in 2 or 3 100 mg 2 times/day. May increase after 3 days to 150 to 450 mg/day. No single dose of bupropion should^ Children and adolescents:^ (Wellbutrin; Wellbutrin SR; Wellbutrin XL) Give as a single 150 mg dose in the morn-^ PO^ : PO:Adults (immediate release^ Initial dose: 3 mg/kg/ 1 10/1/10 9:40:58 AM 0 / 1 / 10 9 : 40 : 58 AM
