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ACKNOWLEDGMENTS

We thank K. A. Evans for illustrations, S. Timmler for the

electron micrograph image, and B. Everitt, T. Robbins, D. Rowitch,

S. Crisp, A. Vanhaesebrouck, H. Pivonkova, S. Hall, K. Evans,

and Y. Kamen for comments on the manuscript.Funding:

Supported by the European Research Council (ERC: the European

Union’s Horizon 2020 research and innovation program grant

agreement 771411; R.T.K., G.B.); the Paul G. Allen Frontiers Group

(Allen Distinguished Investigator program #12076, R.T.K.); the

UK Multiple Sclerosis Society (Centre of Excellence Award #132,

R.T.K.); the Lister Institute of Preventive Medicine (a research

prize, R.T.K.); and the Medical Research Council (grant MR/

N02530X/1, D.B.). The funders had no role in the decision to publish,

nor in the preparation of the manuscript.Competing interests:

The authors have no competing interest to declare.

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