Textbook of Personalized Medicine - Second Edition [2015]

245 tissues where they present antigens to T cells and induce an immune response. Dendritic cells can be derived from CD34+ prec ...

246 antigen for presentation; this should lead to more sustained expression of antigen. The expression of viral (and therefore f ...

247 Concluding Remarks About DC-Based Vaccines DC-based cancer vaccines are a major focus in cancer immunotherapy as the primary ...

248 ACT regimen results in the in vivo expansion and enhanced activity of these cytotoxic lymphocytes. Of the 35 melanoma patien ...

249 Administration of an antibody against mouse VEGF synergized with ACT to enhance inhibition of established, vascularized, B16 ...

250 Genetic Engineering of Tumor Cells Many companies have effective vaccines for stimulating killer T lymphocytes. The missing ...

251 provided evidence of clinical activity only in a minority of patients despite inducing immunization in up to 50 % of them. D ...

252 Table 10.4 Clinical trials of personalized cancer vaccines Vaccine Sponsor Description/indication Phase/status AGS-003 autol ...

253 Personalized Radiation Therapy Radiation therapy is the most common agent used in cancer therapy and up to 60 % of cancer pa ...

254 radiation. Screening blood for the activity level of 24 genes can identify those patients most likely to react badly to radi ...

255 Use of Radiation Sensitivity Biomarkers to Personalized Radiotherapy A systems-biology understanding of radiosensitivity has ...

256 Role of Nanobiotechnology in Personalized Management of Cancer Role of nanobiotechnology in developing personalized approach ...

257 Dendrimers are a novel class of 3D nanoscale, core-shell structures that can be precisely synthesized for a wide range of ap ...

258 Personalized Therapy of Cancer Based on Cancer Stem Cells Cancers may rely on “cancer stem cells” that share the self-renewa ...

259 Epizyme Inc is focused on discovering novel, small molecule drugs that act as selective inhibitors of key epigenetic enzymes ...

260 Sphingolipids Cancer cells are sensitive to nutrient limitation because cancer cell’s ability to generate ATP is compromised ...

261 cell death in both cancer cells and normal cells engineered to have a cancer genotype, irrespective of p53 status, but it ha ...

262 individual protein signals in the molecular weight range from 2,000 to over 200. LCM, in combination with MS, enables acquis ...

263 cancer may be much less relevant to prognosis and response to therapy than the array of causative mutations (Kandoth et al. ...

264 Pharmacogenomic-Based Chemotherapy Whole Genome Technology to Predict Drug Resistance Millennium Pharmaceuticals Inc uses wh ...