Textbook of Personalized Medicine - Second Edition [2015]

xxiii

Personalized Management of Sleep Disorders ......................................... 454

Personalized Therapy of Insomnia ........................................................ 454

Personalized Approach to Chronic Fatigue Syndrome ............................. 455

Personalized Approach to Ataxias ............................................................ 455

Future Prospects of Personalized Neurology ............................................ 456

References ................................................................................................. 456

13 Personalized Management of Psychiatric Disorders ........................... 461
Introduction ............................................................................................... 461
Psychopharmacogenetics/Psychopharmacodynamics .............................. 462
Serotonin Genes .................................................................................... 462
Calcium Channel Gene ......................................................................... 463
Dopamine Receptor Genes ................................................................... 463
Methylenetetrahydrofolate Reductase .................................................. 464
GeneSight Tests for Individualized Therapy
of Psychiatric Disorders ........................................................................ 464
Personalized Antipsychotic Therapy ..................................................... 465
Personalized Antidepressant Therapy ................................................... 467
Personalized Management of ADHD ........................................................ 472
Genotype and Response to Methylphenidate
in Children with ADHD ........................................................................ 473
Pharmaco-EEG for Personalized Treatment of ADHD ........................ 473
Personalized Approach to Addiction ......................................................... 473
Pharmacogenetics of Drug Addiction ................................................... 473
Genetic Polymorphism and Management of Alcoholism ..................... 474
Personalized Therapy for Smoking Cessation ...................................... 475
Future Prospects of Personalized Psychiatry ............................................ 476
References ................................................................................................. 477

14 Personalized Management of Cardiovascular Disorders .................... 479
Introduction ............................................................................................... 479
Cardiogenomics .................................................................................... 479
Role of Diagnostics in Personalized Management
of Cardiovascular Disease ......................................................................... 482
Cardiovascular Disorders with a Genetic Component .......................... 482
Biomarkers and Personalized Management
of Cardiovascular Disorders ................................................................. 488
Pharmacogenomics of Cardiovascular Disorders ................................. 488
Modifying the Genetic Risk for Myocardial Infarction ........................ 489
Personalized Management of Chronic Myocardial Ischemia ............... 489
Management of Heart Failure ............................................................... 490
Management of Hypertension ............................................................... 492
Pharmacogenetics of Lipid-Lowering Therapies .................................. 498
Thrombotic Disorders ........................................................................... 502
Nanobiotechnology-Based Personalized Therapy
of Cardiovascular Diseases ................................................................... 505

Contents