xxii
Personalized Management of Huntington’s Disease ................................. 424
Genomics of Huntington Disease ......................................................... 424
Genetic Testing for HD ......................................................................... 425
Personalized Cell Therapy for Huntington Disease .............................. 425
Personalized Management of Epilepsy ..................................................... 425
Biomarkers of Epilepsy ......................................................................... 426
Genetics/Genomics of Epilepsy ............................................................ 427
Choice of the Right Antiepileptic Drug ................................................ 429
Pharmacogenomics of Epilepsy ............................................................ 429
Pharmacogenetics of Epilepsy .............................................................. 431
Drug Resistance in Epilepsy ................................................................. 431
An Algorithm for Personalized Management of Epilepsy .................... 433
Future Prospects for Management of Epilepsy ..................................... 433
Personalized Management of Migraine .................................................... 435
Pharmacogenomics of Migraine ........................................................... 435
Individualization of Use of Triptans for Migraine ................................ 436
Multitarget Therapeutics for Personalized Treatment of Headache ...... 436
Personalized Management of Stroke ........................................................ 437
Application of Proteomics for Personalizing Stroke Management ....... 437
Brain Imaging in Trials of Restorative Therapies for Stroke ................ 438
Decisions for Evacuation of Intracerebral Hemorrhage ....................... 438
Decisions for Revascularization Procedures
in Chronic Post- stroke Stage ................................................................. 438
Personalized Treatment of Multiple Sclerosis .......................................... 440
Genomics of Multiple Sclerosis ............................................................ 441
Pharmacogenetic Approach to Management of Multiple Sclerosis ...... 441
Immunopathological Patterns of Demyelination
for Assessing Therapy ........................................................................... 442
Personalizing Mitoxantrone Therapy of Multiple Sclerosis ................. 442
Personalized Cell Therapy of Multiple Sclerosis .................................. 443
Pharmacogenomics of IFN-β Therapy in Multiple Sclerosis................ 444
T Cell-Based Personalized Vaccine for MS .......................................... 445
Personalized Management of Pain ............................................................ 446
Genetic Factors in Response to Pain ..................................................... 446
Genetic Mutations with Loss of Pain .................................................... 448
Pharmacogenetics/Pharmacogenomics of Pain ..................................... 448
Mechanism-Specifi c Management of Pain ........................................... 451
Preoperative Testing to Tailor Postoperative
Analgesic Requirements ....................................................................... 451
Personalized Analgesics ........................................................................ 452
Signature of Pain on Brain Imaging ...................................................... 452
Concluding Remarks on Personalized Management of Pain ................ 452
Personalized Management of Traumatic Brain Injury .............................. 454
Molecular Basis of Management of Traumatic Brain Injury ................ 454Contents