715Center for Applied Genomics and Precision
Medicine , 616
Center for Genomic and Computational
Biology , 616, 617
Center of HIV/AIDS vaccine immunology
(CHAVI) , 390
Centers for Disease Control and Prevention
(CDC) , 603, 614
Centers for Education and Research on
Therapeutics (CERTs) , 606
Ceritinib , 347
Charles Bronfman Institute for Personalized
Medicine , 621
ChemoFx assay , 224, 321
Chemotherapy
brain cancer
EGFR inhibitors , 286–287
methylation testing , 286
breast cancer ( see Breast cancer
management)
Chimeric antigen receptor (CAR) , 249
Chloramphenicol , 107, 384
Chronic disease (CD) , 582, 699
Chronic fatigue syndrome (CFS) , 455
Chronic hepatitis B (CHB) , 94, 401, 402
Chronic lymphocytic leukemia (CLL) , 209,
276, 331–332
Chronic myeloid leukemia (CML) , 207, 275,
276, 326
Chronic obstructive pulmonary disease (COPD)
biomarkers
alpha1-antitrypsin , 522
chromagranin A , 523
lung failure , 522
gene expression analysis , 523–524
interstitial lung disease , 525–526
management , 524–525
prognosis of , 524
Circadian rhythms , 180–181
Circulating tumor cells (CTCs) , 357
BEAMing technology , 206–207
clinical cancer dormancy , 239
isolation and characterization of , 211
LOH detection , 206
in metastatic breast cancer , 300–301
NanoFlares for , 212
nanoparticles and X-rays , 234
Classifi cation of Ovarian Cancer (CLOVAR) , 320
Clinical and Laboratory Standards Institute
(CLSI) , 676
Clinical Genomic Database (CGD) , 24
Clinical laboratory , 598
Clinical Proteomics Program , 613
Cloning , 192
CNV. See Copy number variation (CNV)
Collaborative Molecular Environment , 597
Colorectal cancer (CRC) , 212
chemotherapy , 339
DNA microarray analysis , 340
EGFR blockade , 344–345
genetic and epigenetic alterations , 339
HNPCC , 338
KRAS mutations , 340
LINE-1 methylation , 341
OncoTrack , 342
sequencing analyses , 342–343
systems biology approach , 344
COLTHERES consortium , 366
Committee on Environmental Exposure
Technology Development , 182
Community-acquired pneumonia (CAP)
BNP , 514
clinical risk scores , 513
plasma biomarkers , 514
urinary nitric oxide , 514–515
Companion diagnostics , 82–84, 594–595,
674–676
Comparative effectiveness research (CER) ,
605–608, 704
Comparative genomic hybridization (CGH) ,
11, 532
Computational and Applied Genomics
Program , 642
Connected health (CH) , 699
COPD. See Chronic obstructive pulmonary
disease (COPD)
Copy-number breakpoints (CNBs) , 222
Copy number variation (CNV)
CNVer algorithm for , 71
digital array for , 71
discovery and genotyping, CNVnator , 71–72
GWAS , 70
in human genome , 11–13
real-time PCR reaction , 39
Coriell Personalized Medicine Collaborative™
(CPMC™) , 615–616
Coronary heart disease (CHD) , 662
gene mutations , 482, 484
KIF6 gene test , 485
SNPs , 487
testing in , 487–488
Cough variant asthma (CVA) , 517
CRC. See Colorectal cancer (CRC)
Crizotinib , 347, 682
CSBs. See Cancer signaling bridges (CSBs)
CTCs. See Circulating tumor cells (CTCs)Index