716
CUB domain-containing protein 1 (CDCP1) , 233
Current Procedural Terminology (CPT)
codes , 629
Cyclodextrin-modifi ed micellar electrokinetic
capillary chromatography
(CD-MECC) , 172–173
Cyclooxygenase-2 (COX-2) inhibitors , 141,
338, 557, 594
Cystic fi brosis (CF) , 533
carrier screening , 547
diagnosis of , 547
gene therapy , 548
mutations and DNA sequence variations , 547
personalized medicine, cost of , 686
pharmacogenomic approach , 548
protein misfolding , 162
treatment , 547–548
Cytomics , 179, 184–185
Cytosine arabinoside , 230
Cytotoxic T lymphocytes (CTL) , 248, 338
D
Dacomitinib , 349, 366
DatabasE of Chromosomal Imbalance and
Phenotype in Humans using Ensembl
Resources (DECIPHER) , 540
Data Monitoring Committee (DMC) , 397
DCVax , 245
Deciphering Development Disorders (DDD)
program , 540–541
Delaware Valley Personalized Medicine
Project (DVPMP) , 616
Denaturing high-performance liquid
chromatography (DHPLC) , 38
Deoxycytidine kinase (DCK) , 231
Department of Health and Human Services
(DHHS) , 604–605, 640
Diabetes mellitus (DM) , 565–566
DIASTAT™ anti-cyclic citrullinated peptides
(CCP) , 557
Differentiated thyroid cancer (DTC) , 364
Dihydrofolate reductase (DHFR) , 384
Dihydropyrimidine dehydrogenase (DPD) ,
267–268
Dinitrophenyl (DNP) , 243
DirectLinear™ analysis , 37
Direct-to-consumer (DTC) genetic screening
tests , 87
ethical aspects of , 657–658
regulation of , 676–680
Disease modifying antirheumatic drugs
(DMARD) , 555, 557
Double-stranded RNA (dsRNA) , 195
Down’s syndrome , 534–535
Duchenne muscular dystrophy (DMD)
biomarkers , 535
gene therapy approaches , 544–547
Ductal carcinomas in situ (DCIS) , 295
Duke University Medical Center (DUMC) ,
616–617E
Economics, personalized medicine
blockbuster drugs , 681
healthcare cost
diagnostics and therapeutics,
combination of , 687–688
genetic testing and , 687
in US , 686–687
orphan drug syndrome , 682
pharmacogenetics
adverse drug reactions , 688–689
costs of , 688
pharmacogenomics
cancer chemotherapy , 691
clinical trials , 685
DNA testing , 682
genotyping , 684–685
HIV genotyping , 689
human genome sequencing , 683–684
KRAS and BRAF screening, CRC
patients , 690
warfarin , 690
EGFR. See Epidermal growth factor receptor
(EGFR)
Electronic health records (EHRs)
DHHS , 638
GenePING , 640
genetic research , 641–642
genome-wide studies , 639
health care expenditures, savings in ,
638–639
healthcare organizations , 638
HITECH , 638
IBM’s GMS , 639–640
new medicines, safety of , 640–641
personalized drug discovery and
development , 642
US hospitals, adoption in , 638
Electronic Medical Records and Genomics
Network (eMERGE) , 611, 641
Embryonic stem cells (ESCs) , 191
Emphysema , 162, 163, 522
ENCyclopedia Of DNA Elements
(ENCODE) , 6–7
Environmental factors, disease , 181–183Index