ECMO-/ECLS

 child 90mg/kg

 >60kg – 4000mg

o IV dose 15mg/kg q6 hours ages 2-12 years; age >12

years 1g q6 hours

 max daily dose

 ages 2-12 years or <50kg: 75mg/kg/day

 >12 years and >50kg: 4g/day

 Onset: 30 minutes

 Precautions: hepatotoxicity at high doses

2. Etomidate [23,24]^
   Carboxylated imidazole, IV general anesthetic, diluted in
   propylene glycol
    Clinical indications: induction and maintenance of anesthesia.
   Procedural sedation. No analgesic properties.
    Clinical effects: ultra-short acting non-barbiturate hypnotic
   o Minimal cardiovascular effects – often used in patients
   with impaired cardiovascular function
   o Dose dependent depressant respiratory effects
   o Decreases cerebral metabolic rate, causing dereased
   cerebral blood flow and decreased ICP - used in
   patients with elevated ICP and closed head injury