- Meperidine [13]^
Metabolized into normeperidine, which is toxic metabolite that can
accumulate in patients with liver disease and cause seizures.
Dosing 1mg/kg q 2 - 3 hours
B. Non opioids
- Acetaminophen [2,13]^
Clinical indications: treatment of mild to moderate pain,
antipyretic
Clinical effects: Effects centrally by inhibiting COX 3. Has
additive effect to opioids. No tolerance or respiratory
depression.
Safe for use in neonates. Has same analgesic efficacy as 0.5-
1mg/kg codeine.
Dosing:
o rectal doses 20-25mg/kg
o PO dose 10-15mg/kg q4-6 hours
Max daily doses
preterm 60mg/kg
term 80mg/kg