Science - USA (2022-01-28)
A. G. Knudson Jr., Mutation and cancer: Statistical study of retinoblastoma.Proc. Natl. Acad. Sci. U.S.A. 68 , 820– 823 (1971). ...
RESEARCH ARTICLE SUMMARY ◥ NEURODEVELOPMENT Nests of dividing neuroblasts sustain interneuron production for the developing huma ...
RESEARCH ARTICLE ◥ NEURODEVELOPMENT Nests of dividing neuroblasts sustain interneuron production for the developing human brain ...
the hMGE during an extended period of prenatal development suggests that this orga- nization is fundamental to the production of ...
(table S2). vRG contacted the ventricle through thin apical expansions that had apical junc- tions and a primary cilium. Their n ...
and mitochondria, and their expansions were thicker and longer; this may reflect a higher degree of differentiation and activati ...
enriched as punctate staining in the 22 GW hMGE, but not in hLGE. E2F1 staining fre- quently overlapped with DCX staining. Unlik ...
were found dispersed into many regions of the mouse brain including the hippocam- pus, amygdala, corpus callosum, striatum, sept ...
Paredeset al.,Science 375 , eabk2346 (2022) 28 January 2022 7 of 10 3:16:04 3:16:04 5:01:36 5:01:36 6:47:08 6:47:08 8:32:41 8:32 ...
F and G). Patch-clamp recording in slices prepared at 50 DAT showed that the majority (12/13) of GFP+hMGE-derived cells had im- ...
SOX2 is a transcription factor present in stem cells and is necessary for their progression to neural fates. Yet SOX2 also funct ...
C. P. Wonders, S. A. Anderson, The origin and specification of cortical interneurons.Nat. Rev. Neurosci. 7 , 687–696 (2006). do ...
RESEARCH ARTICLES ◥ STRUCTURAL BIOLOGY Structure-based discovery of nonhallucinogenic psychedelic analogs Dongmei Cao^1 †, Jing ...
the OBP (Fig. 1B). Other aminergic receptors have an alanine, serine, cysteine, or threonine at this position and the side chain ...
Serotonin and psilocin have a second binding mode at 5-HT2AR Unlike previous docking results ( 23 ), our crystal structures show ...
We previously reported that differences in ligand recognition in the EBP, specifically at TM7, result in divergent effects on li ...
that the two ethyl groups of LSD contact residue Y3707.43(Y, tyrosine), which only interacts with one ethyl group of lisuride (F ...
408 28 JANUARY 2022¥VOL 375 ISSUE 6579 science.orgSCIENCE Fig. 4. Effects of the designed 5-HT2AR agonists on animal behavior re ...
(DOI), another commonly used psychedelic that shows greatly attenuated HTR in Gqknock- out mice ( 36 ), produced an HTR of equal ...
lisuride, induced a significant HTR in mice (figs. S7A and S8, A to D). To our surprise, IHCH-7079 and IHCH-7086 failed to produ ...
«
1
2
3
4
5
6
7
»
Free download pdf