Govindachari et al, 1969). Leaves contain homoandrographolide, andrographosterol and
andrographone.
The plant is vulnerary, antipyretic, antiperiodic, anti-inflammatory, expectorant,
depurative, sudorific, anthelmintic, digestive, stomachic, tonic, febrifuge and cholagogue.
The plant is antifungal, antityphoid, hepatoprotective, antidiabetic and cholinergic. Shoot is
antibacterial and leaf is hypotensive(Garcia et al, 1980). This is used for the inflammation of
the respiratory tract. In China, researchers have isolated the andrographolide from which
soluble derivative such as 14-deoxy-11, 12-dehydro-andrographolide which forms the
subject of current pharmacological and clinical studies. Apigenin 7,4’-O-dimethyl ether
isolated from A. paniculata exhibits dose dependent, antiulcer activity in shay rat, histamine
induced ulcer in guinea pigs and aspirin induced ulcers in rats. A crude substance isolated
from methanolic extract of leaves has shown hypotensive activity. Pre-treatment of rats with
leaf (500mg/kg) or andrographolide (5mg/kg) orally prevented the carbon tetrachloride
induced increase of blood serum levels of glutamate-oxaloacetate transaminase in liver and
prevented hepatocellular membrane.
ron
(Ron)
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