Principles and Practice of Pharmaceutical Medicine
...
4 Drug Discovery: Design and Serendipity Ronald R. CobbandLeslie J. Molony 4.1 Introduction How is it that medicines are discove ...
will become marketed products, and among those only about a half will produce financial returns that are disproportionately high ...
Once a direction is chosen, it must be validated scientifically, within a defined biological system. Human disease or pathology ...
(TNF) antibodies in human rheumatoid arthritis. There would also have been a lot of data available concerning cellular infiltrat ...
with the binding of the transcription regulatory complex to DNA. A key decision in each lab is when to incur the expense, and ti ...
activity and abundance does not always correlate with mRNA levels (Chenet al., 2002; Gygiet al., 1999). The ‘one-gene-one-protei ...
organs and organisms, with their emergent proper- ties that define the discipline of complex systems biology.In vivocells operat ...
Beeley LJ, Duckworth DM. 1996. The impact of geno- mics on drug design.Drug Discov. Today 1 (11): 474–480. Chapman D. 1996. The ...
5 Pharmaceutics Anthony W. Fox 5.1 Introduction It is a triumph of modern pharmaceutics that most of us do not give a thought to ...
5.2 The constituents of a medicine ‘A drug is not a drug is not a drug’ because, when administered to a human being, in the gene ...
for bladder dysfunction and migraine prevention, and claimed to be innocuous on grounds of chemi- cal purity but without much bi ...
swallowing and gastrointestinal absorption (e.g. rizatriptan wafer). Benzocaine lozenges are intended for the same purpose but t ...
bioequivalence study designs are also available. Rarely, the testing of bioequivalence at steady state in patients is needed bec ...
Gases The physics of gases and the partial pressure at which they can achieve anesthesia is beyond the scope of this chapter. Fo ...
whether or not the patient is actually having an asthma attack (Patelet al., 1990); breathing pattern, airway calibre, device ...
nasal sprays and aerosols. While the intent of this guideline is to facilitate the development of generic products for use by th ...
then an anhydrous environment is needed for pro- duct stability. This is most easily achieved as a lyophilized powder in an evac ...
For example, the dry-powder inhaler was initially devised for sodium cromoglycate (which is almost insoluble), but it is now als ...
in mild asthma’.Am. Rev. Resp. Dis. 141 : 357– 360. Snell NJ, Ganderton D. 1999. ‘Assessing lung deposi- tion of inhaled medicat ...
«
1
2
3
4
5
6
7
8
9
10
»
Free download pdf