Comparative and Veterinary Pharmacology

7 Conclusions An appreciation of the multi-faceted mechanisms through which antimicrobial drugs can exert their therapeutic effe ...

to remember that, it is the host immune system that is ultimately responsible for success in combating bacterial disease. Refere ...

Chambers HF (2006) General Principles of Antimicrobial Therapy. In: Brunton LL, Lazo J, Parker K (eds) Goodman Gilman’s the phar ...

Duckworth DH, Gulig PA (2002) Bacteriophages: potential treatment for bacterial infections. BioDrugs 16:57–62 Duquette RA, Nutta ...

Jensen VF, Neimann J, Hammerum AM, Molbak K, Wegener HC (2004) Does the use of anti- biotics in food animals pose a risk to huma ...

Melchior MB, van Osch MH, Graat RM, van Duijkeren E, Mevius DJ, Nielen M, Gaastra W, Fink-Gremmels J (2009) Biofilm formation an ...

Preston SL, Drusano GL, Berman AL, Fowler CL, Chow AT, Dornseif B, Reichl V, Natarajan J, Corrado M (1998) Pharmacodynamics of l ...

Tateda K, Standiford TJ, Pechere JC, Yamaguchi K (2004) Regulatory effects of macrolides on bacterial virulence: Potential role ...

Drug Residues Philip T. Reeves Contents 1 Introduction ......................................................................... ...

constitute a health hazard to consumers. Non-regulatory organizations, including the veterinary pharmaceutical industry, produce ...

the international trade in animal-derived food commodities by requiring exporters to comply with a diverse range of standards im ...

animal-derived foods is also facilitated when these principles and methods of the risk analysis framework are applied consistent ...

to the physicochemical properties of the pure active ingredient, the purity of the test substance, and any impurities present. 2 ...

and for variation within humans. Guidance on the selection of appropriate safety factors has been published (IPCS 1987 ), and it ...

non-genotoxic carcinogens may be regulated using a threshold approach such as the NOEL-safety factor approach described above. A ...

high percentile (commonly the 95%) of the distribution of marker residue present in tissues of treated animals. By comparison, t ...

consumption factors for the standard edible tissues (3). Only that portion of the ADI not reserved for milk or eggs is available ...

there is evidence of genotoxicity in vitro; in addition, a dose–response relationship or threshold dose for the induction of apl ...

A marker residue compound and a target tissue are selected on the basis of the findings of metabolism studies. A marker residue ...

Median Residue 2 first iter ation Median Residue 1 Median Residuen MRL 1 MRL 2 MRLn × × × Metabolism and pharmacokinetic studies ...