PDR for Herbal Medicines

(Barré) #1
HERBAL MONOGRAPHS SENNA /687

Bowel Evacuation:

Liquid (alcohol 7% by volume) — Adults and children 12
years of age and older should take one bottle between 2 and
4 p.m. on day prior to x-ray or other diagnostic procedures.
Drink entire contents of bottle. A strong bowel action can be
expected approximately 6 hours after drinking the prepara-
tion (Prod Info X-Prep®,1998).

Storage: Senna should be protected from light (DAB 10
EUR), and stored for a maximum of 3 years (2.AB-DDR).

LITERATURE
Agra Y; Sacristan A: Gonzalez M et al. Efficacy of senna
versus lactulose in terminal cancer patients treated with opioids.
J Pain Symptom Manage 1998 Jan: 15(1): 1-7.
al-Dakan AA; al-Tuffail M; Hannan MA. Cassia senna inhibits
mutagenic activities of benzo[a]-pyrene, aflatoxin Bl, shamma
and methyl methanesulfonate. Pharmacol Toxicol 1995
Oct;77(4):288-92.
Anonym, Sennahaltige Laxanzien: Alte Arzneipflanze in neuem
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BGA, Arzneimittelrisiken: Anthranoide. In: DAZ 132(21): 1164.


  1. .. V -
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    of melanosis coli: a lectin histochemical study. Gastrointest
    Endosc 1997 Aug;46(2):131-8.
    Beubler E, Kollar G. Stimulation of PGE2 synthesis and water
    and electrolyte secretion by senna anthraquinones is inhibited by
    indomethacin. J Pharm Pharmacol 1985 Apr,37(4):248-51.
    Beubler E; Kollar G. Prostaglandin-mediated action of
    sennosides. Pharmacology 1988:36 Suppl 1:85-91.
    Choi JS et al.. In vitro antimutagenic effects of anthraquinone
    aglycones and naphthoquinones. In: PM 63(1): 11-14. 1997.
    Christ B et al., (1978) Arzneim Forsch 28:225.
    Donowitz M; Wicks J: Battisti L et al. Effect of Senokot on rat
    intestinal electrolyte transport. Evidence of Ca+ dependence.
    Gastroenterology 1984 Sep:87(3):503-12.
    Dufour P, Gendre P, (1988) Long-Termin mucosal alterations
    by sennosides, related compounds. Pharmacology 36(Suppl
    1): 194-202.
    Fairbaim JW (1964) Lloydia 27:79.
    Fairbairn JW (1976) Pharmacol 14(Suppl 1):48.
    Fairbaim JW, Shrestha AB, (1967) Lloydia 30:67.
    Helin T; Makinen-Kiljunen. Occupational asthma and
    rhinoconjunctivitis caused by senna. Allergy 1996
    Mar;51(3): 181-4.


Jahn K et al., Toxicology of Cassia fikifiki Aubreville 6
Pellegrin in relation to other species of the genus Cassia (s.l.).
In: PM 62, Abstracts of the 44th Ann Congress of GA, 57.
1996.


Joo JS; Ehrenpreis ED; Gonzalez L et al. Alterations in colonic
anatomy induced by chronic stimulant laxatives: the cathartic
colon revisited. J Clin Gastroenterol 1998 Jun;26(4):283-6.
Klimpel BE et al., Anthranoidhaltige Laxantien - ein Risiko fur
die Entwicklung von Tumoren der ableitenden Harnwege. In:
PUZ 26(1):33, Jahrestagung der DPhG, Berlin, 1996. 1997.
Lemli J, Cuveele J. (1975) Phytochemistry 14:1397.
Lemli, J et al., (1981) Planta Med 43:11.
Leng-Peschlow E. Mengs U, Sennalaxantien: Sicher und
wirksam. In: PZ 140(8):668-676. 1995.
Levine D; Goode AW; Wingate DL. Purgative abuse associated
with reversible cachexia, hypogammaglobulinaemia, and finger
clubbing. Lancet 1981 Apr 25; 1(8226):919-20. -" :-
Lewis SJ, Oakey RE. Heaton KW. Intestinal absorption of
estrogen: the effect of altering transit-time. Eur J Gastroenterol
Hepatol 1998 Jan;10(l):33-9.
Malmquist J; Ericsson B; Hulten-Nosslin MB et al. Finger
clubbing and aspartylglucosamine excretion in a laxative-abusing
patient. Postgrad Med J 1980 Dec;56(662):862-4.
Marks GB; Salome CM; Woolcock AJ. Asthma and allergy
associated with occupational exposure to ispaghula and senna
products in a pharmaceutical work force. Am Rev Respir Dis
"1991 Nov;144(5): 1065-9.
Mereto E; Ghia M; Brambilla G. Evaluation of the potential
carcinogenic activity of Senna and Cascara glycosides for the
rat colon. Cancer Lett 1996 Mar 19;l01(l):79-83.
Prior J, White I. Tetany and clubbing in patient who ingested
large quantities of senna. Lancet 1978 Oct 28;2(8096):947.
Product Information: Ex-Lax®, chocolated laxative pieces.
Novartis, Summit. NJ, USA, 1998.
Product Information: Ex-Lax®, regular and maximum strength
laxative pills. Novartis, Summit, NJ, USA, 1998.
Product Information: SenokotXTRA®, standardized senna
concentrate. Purdue Frederick, Norwalk, CT, USA, 1993.
Product Information: Senokot®, extract of standardized senna.
Purdue Frederick, Norwalk, CT, USA, 1991.
Product Information: Senokot®, standardized senna concentrate.
Purdue Frederick, Norwalk, CT, USA, 1993.
Product Information X-Prep®, extract of standardized senna.
Gray Pharmaceuticals, Norwalk, CT, USA, 1998.
Schultze W, Jahn K, Richter R, Volatile constituents of the
dried leaves of Cassia angustifolia and C. acutifolia (Sennae
folium). In: PM 61(6):540-543. 1996.
Silber W, Spriihgetrockneter Senna-Extrakt. In: DAZ
131(9):349. 1991.
Silk DB; Gibson JA; Murray CR. Reversible finger clubbing in
a case of purgative abuse. Gastroenterology 1975 Apr;68(4 Pt
I):790-4.
Sprecher E, Uber die Qualitat von Phytopharmaka. In: ZPT
r 12(4): 105. 1991.
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