Decongestants (sympathomimetic amines),
257–258
Delavirdine (Rescriptor, DLV), 319
Democlocycline (Declomycin), 234t
Dependence versus tolerance, 37, 71–72
Depression, 297–298, 301
bipolar affective (manic-depressive), 298
major (unipolar), 298
reactive (exogenous), 298
side effects of antidepressants, 299t–300t
Desmopressin, 387
Desonide (Tridesilon), 379t
Desoximetasone (Topicort), 379t
Despramine (Norpramin), 299t
Dexamethasone (Decadron), 334
Diabetes mellitus
signs and symptoms, 393
type I, 392
type II, 392–393
Diazepam (Valium), 70t,290, 294, 297
Diazoxide (Proglycem), 396
Dichlorphenamide (Darnide, Oratrol), 361
Dicloxacillin (Dynapen), 211t
Didanosine (Videx, ddI), 319
Diet, well-balanced, 138–139, 139t–140t
Diethylcarbamzine (Hetrazan), 250
Diffusion, 26, 254
Diflorasone (Florone), 379t
Digitalis glycosides, 350
Digoxin (Lanoxin), 31, 350
Digoxin immune fab (Ovine, Digibind)
Diltiazem (Cardizem), 352, 354t
Diphenidol (Vontrol), 334
Direct-acting arteriolar vasodilators, 357
Distribution, 84
bloodflow, 30
competing drugs, 30–31
elderly patients, 56
level of plasma protein, 30
overview, 29–30
Diuretics, 351, 356–357
carbonic anhydrase inhibitors, 361, 363
loop or high-ceiling diuretics, 360–362
osmotic diuretics, 360, 362
overview, 359–360
potassium-sparing diuretics, 361, 363–364
thiazide and thiazide-like diuretics, 360–361
Dobutamine (Dobutrex), 285t
Donepezil (Aricept), 292
Dong quai (Angelica sinesis), 132
Dopamine (Intropin), 285t
Dopamine antagonists, 333
Dose calculations
formulas, 117–119
metric system
converting, 116–117
household measurements, 115, 115t
overview, 113–114, 114t
overview, 113, 121–122
parenteral medications, 119–121
calculating IV flow rate for continuous or
intermittent (piggyback) infusions,
120–121
heparin infusion, 121
quiz, 122–123
Doxazosin (Cardura), 285, 286t
Doxepin (Sainequan), 299t
Doxorubicin
contraindicated with breastfeeding, 55
Doxycycline, 233, 235t
D-propoxyphene (darvon), 70t
Droperidol (Inapsine), 333
Drug action and drug interactions, 24, 35, 86
absorption rate
circulation, 27
overview, 26–27
pH level, 28
route of administration, 27
solubility, 27–28
bioavailability, 28–29
distribution
bloodflow, 30
competing drugs, 30–31
level of plasma protein, 30
overview, 29–30
drug actions, 24, 35
drug concentration, 29
elimination, 31–32
first pass effect, 33
overview, 23, 38–39
pharmaceutic phase, 24–25, 25t
pharmacodynamics
overview, 33–34
receptor theory, 34–35Index^443