Science - USA (2022-02-25)

796 25 FEBRUARY 2022 • VOL 375 ISSUE 6583 science.org SCIENCE

GRAPHIC: KELLIE HOLOSKI/

SCIENCE

RESEARCH

IN BRIEF

832 From Science and other journals

REVIEW

835 Solar cells
Rethinking the A cation in halide perovskites
J. -W. Le e et al.
REVIEW SUMMARY; FOR FULL TEXT:
DOI.ORG/10.1126/SCIENCE.ABJ

RESEARCH ARTICLES

836 Human evolution
A unified genealogy of modern and ancient
genomes A. W. Wohns et al.
RESEARCH ARTICLE SUMMARY; FOR FULL TEXT:
DOI.ORG/10.1126/SCIENCE.ABI
PERSPECTIVE p. 817

837 Nanophotonics
A framework for scintillation in
nanophotonics C. Roques-Carmes et al.
RESEARCH ARTICLE SUMMARY; FOR FULL TEXT:
DOI.ORG/10.1126/SCIENCE.ABM
PERSPECTIVE p. 822

838 Neuroscience
Hyperexcitable arousal circuits drive sleep
instability during aging S.-B. Li et al.
RESEARCH ARTICLE SUMMARY; FOR FULL TEXT:
DOI.ORG/10.1126/SCIENCE.ABH
PERSPECTIVE p. 816

839 Protein targeting

Mechanism of signal sequence handover

from NAC to SRP on ribosomes during

ER-protein targeting A. Jomaa et al.

845 Structural biology

Dynamics and mechanism of a light-driven

chloride pump S. Mous et al.

852 Nanomaterials

Highly stretchable van der Waals thin films

for adaptable and breathable electronic

membranes Z. Yan et al.

REPORTS

859 Immunology

Trained ILC3 responses promote intestinal

defense N. Serafini et al.

864 Coronavirus

Structural basis of SARS-CoV-2 Omicron

immune evasion and receptor engagement

M. McCallum et al.

869 Organic chemistry

Deracemization through photochemical E/Z

isomerization of enamines M. Huang et al.

874 Black holes

Black hole spin–orbit misalignment in the

x-ray binary MAXI J1820+

J. Poutanen et al.

PERSPECTIVE p. 821

877 Cancer immunology

Molecular signatures of antitumor

neoantigen-reactive T cells from metastatic

human cancers F. J. Lowery et al.

884 Optics

Topological modes in a laser

cavity through exceptional state transfer

A. Schumer et al.

889 Antibiotic resistance

Minimizing treatment-induced

emergence of antibiotic resistance

in bacterial infections M. Stracy et al.

PERSPECTIVE p. 818

894 Organic chemistry

Total synthesis of himastatin

K. A. D’Angelo et al.

PERSPECTIVE p. 820

ON THE COVER

A reconstruction of multiple optical slices

from the developing eye of a fruit fly

(Drosophila melanogaster) larva. Each

observed photoreceptor neuron expresses

one of three protein tags (either alone or in

combination), corresponding to different

colors. The neurons maintain their spatial

proximity while sending projections to the

brain. The Gordon Research Conference on

Neural Development

will be held from 7 to 12

August 2022 in Newport,

Rhode Island. See page

900 for the Gordon

Research Conferences

schedule and preliminary

programs. Image:

Amanda A. G. Ferreira

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CONTENTS

DEPARTMENTS

797 Editorial

We are all Gang Chen By G. Chen

930 Working Life

It’s not (all) about you By J. R. Posselt

Gordon Research Conferences ................ 900

Science Careers ........................................ 928

POLICY FORUM

825 Streamlining ethics review for
international health research
Single-site review means protection and
efficiency By Mark A. Rothstein et al.

LETTERS

827 Plans to protect China’s
depleted groundwater
By C. Zheng and Z. Guo

827 Transparency crucial to
Paris climate scenarios
By L. King et al.

828 Response
B y Y. O u et al.

PRIZE ESSAY

829 Why do people die from COVID-19?
Autoantibodies that neutralize
type I interferons increase with age
By P. Bastard

821 & 874

Banca do Antfer

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