Biology of Disease

immature and mature myeloid cells within the bone marrow and spleen. Chronic myelogenous leukemia usually follows a clinical pat ...

Patients present with anemia and bruising due to inadequate production of erythrocytes and platelets respectively. Poor platelet ...

joints and bones and a general feeling of malaise. Diagnosis is achieved by microscopic examination of bone marrow taken from th ...

17.9 Summary Cancer is a group of diseases in which cells escape from the usual regulatory factors controlling cell division and ...

Which of the following are the four most common tumor sites in adults in the UK? a) Lung, breast, colorectum and bone marrow; ...

Donaldson, MS (2004) Nutrition and cancer: a review of the evidence for an anti-cancer diet. Nutr. J.3: 19–40. El-Deiry, WS (200 ...

X]VeiZg&,/ CANCER *&) W^dad\nd[Y^hZVhZ Useful web sites: The National Institute for Clinical Excellence (NICE) publis ...

& X]VeiZg&-/ AGING AND DISEASE 18.1 Introduction Aging is difficult to define but is perhaps most widely understood to ...

expectancy has increased over the last 100 years, the human life span, that is, the maximum age that can be attained by members ...

and wearing of spectacles becomes a necessity. Changes also occur in the lens proteins, the crystallins, causing them to become ...

X]VeiZg&-/ AGING AND DISEASE *&- W^dad\nd[Y^hZVhZ Type I collagen is the major collagen (Figure 18.3A, BandC) in the ...

18.3 Causes of Aging A number of theories have been proposed to explain cellular aging. These theories can be divided into two b ...

Glycated proteins Both intra- and extracellular proteins are subject to posttranslational changes during aging. For example, pro ...

newly synthesized enzyme. Unfortunately, such repair mechanisms lose their efficacy as the cell ages. Genome-Based Theories Ther ...

from younger mice. In addition, liver cells obtained from strains of mice with a short lifespan show a higher incidence of mutat ...

the high incidence of mortality from coronary heart disease especially if other risk factors are present. This risk may be decre ...

X]VeiZg&-/ AGING AND DISEASE *') W^dad\nd[Y^hZVhZ BOX 18.2 The young and old of aging: Hutchinson-Gilford syndrome (proge ...

AGE-RELATED DISEASES CZhhVg6]bZY!BVjgZZc9Vlhdc!8]g^hHb^i]:YLddY ' tissue even after neuron death. They consist mainly o ...

X]VeiZg&-/ AGING AND DISEASE *'+ W^dad\nd[Y^hZVhZ BOX 18.2 The young and old of aging: Hutchinson-Gilford syndrome (proge ...

INVESTIGATIONS AND MANAGEMENT OF THE ELDERLY CZhhVg6]bZY!BVjgZZc9Vlhdc!8]g^hHb^i]:YLddY *', 18.5 Calorie Restriction an ...