- “Besides antibiotics, there is the mounting use of other agents aimed at
destroying bacteria, namely the surface antibacterials now available in many
household products. These too enter the environment. The stage is thus set for an
altered microbial ecology.” - “In order to curb the resistance problem, we must encourage the return of the
susceptible commensal flora. They are our best allies in reversing antibiotic
resistance.” - “Confronted by increasing amounts of antibiotics over the past 60 years, bacteria
have responded to the deluge with the propagation of progeny no longer
susceptible to them.” - “Antibiotic residues can be found in the environment for long periods of time
after treatment.”
Levy, S. and Marshall, B. (2004). Antibacterial resistance worldwide: Causes,
challenges and responses. Nature Medicine Supplement 10(12). pg. S122-9.
http://www.nature.com/nm/journal/v10/n12s/abs/nm1145.html
- “Today, clinically important bacteria are characterized not only by single drug
resistance but by multiple antibiotic resistance – the legacy of past decades of
antimicrobial use and misuse.”
Li, J., Nation, R. L., Milne, R. W. et al. (2005). Evaluation of colistin as an agent
against multi-resistant Gram-negative bacteria. International Journal of Antimicrobial
Agents. pg. 11-25. http://www.ijaaonline.com/article/S0924-8579(04)00365-6/pdf
- “The widespread resistance of microorganisms to antibiotics threatens to be a
future medical diaster.” - “Infections caused by multi-resistant Gram-negative bacteria, particularly
Pseudomonas aeruginosa, are incrasing worldwide. In patients with cystic
fibrosis (CF), resistance in P. aeruginosa to numerous anti-pseudomonal agents
is becoming common...It is likely that colistin will be an important antimicrobial
option against multi-resistant Gram-negative bacteria, for some years to come.” - Not so many years as the medical community would have liked.
Li, J. and Vederas, J. (2009). Drug discovery and natural products: End of an era or an
endless frontier? Science. 325(5937). pg. 161-5.
http://www.ncbi.nlm.nih.gov/pubmed/19589993
- “Pharmaceutical research expanded after the Second World War to include
massive screening of microorganisms for new antibiotics because of the