750 APPENDIX B DRUG FORMULARY
Drug name (trade orother names)
Pharmacology andindications
Adverse effects andprecautions
Dosing information andcomments
Formulations
Dosage (unlessotherwise indicated,dose is the same fordogs and cat)
Amphotericin B,liposomal formulation(ABLC, Abelcet)
Same indications as forconventionalamphotericin B. Liposomalformulations may be usedat higher doses, andsafety margin is increased.Expense is much higherthan for conventionalformulations.
Renal toxicity is the mostdose-limiting effect.
Higher doses can be usedcompared to conventionalformulation ofamphotericin B. Dilute in5% dextrose in water to1 mg/mL, and administerIV over 1–2 hours.
100 mg/20 mL inlipid formulation.
Dog: 2–3 mg/kg IV 3times/week for 9–12treatments to acumulative dose of24–27 mg/kg.Cat: 1 mg/kg IV 3times/week for 12treatments.
Ampicillin (Omnipen,Principen, others[human forms])
β-lactam antibiotic.Inhibits bacterial cell wallsynthesis.
Use cautiously in animalsallergic to penicillin-likedrugs.
Dose requirements varydepending onsusceptibility of bacteria.Absorbed approximately50% less, compared withamoxicillin, whenadministered orally.Generally, more frequentor higher doses neededfor gram-negativeinfections.
250, 500 mgcapsules; 125, 250,500 mg vials ofampicillin sodium.Ampicillintrihydrate: 10 and25 g vials forinjection.
Ampicillin sodium:10–20 mg/kg q6–8h IV,IM, SC or 20–40 mg/kgq8h po. Ampicillintrihydrate: Dog:10–50 mg/kg q12–24hIM, SC.Cat: 10–20 mg/kgq12–24h IM, SC.
Antacid drugs
See Aluminum hydroxide,Magnesium hydroxide,Calcium carbonate.
Atipamezole(Antisedan)
α^2
-antagonist. Used to
reverse
α^2
-agonists, such
as medetomidine andxylazine.
Safe. Can cause someinitial excitement in someanimals shortly afterreversal.
When used to reversemedetomidine, injectsame volume as used formedetomidine.
5 mg/mL injection
Inject same volume asused for medetomidine.
