786 APPENDIX B DRUG FORMULARY
Drug name (trade orother names)
Pharmacology andindications
Adverse effects andprecautions
Dosing information andcomments
Formulations
Dosage (unlessotherwise indicated,dose is the same fordogs and cat)
Lincomycin (Lincocin)
Lincosamide antibiotic,similar in mechanism toclindamycin anderythromycin. Spectrumincludes primarilygram-positive bacteria.Used for pyoderma andother soft tissueinfections.
Adverse effectsuncommon. Lincomycinhas caused vomiting anddiarrhea in animals. Donot
administer orally to
rodents and rabbits.
Action of lincomycin andclindamycin is similarenough that clindamycincan be substituted forlincomycin.
100, 200, 500 mgtablets.
15–25 mg/kg q12h po.For pyoderma, doses aslow as 10 mg/kg q12hhave been used.
Linezolid (Zyvox)
Oxazolidinone antibiotic.Gram-positive spectrumthat includesdrug-resistant strains ofEnterococcus
and
Staphylococcus
.High
expense limits routine use.
Adverse effects includediarrhea and nausea.Rarely in people, anemiaand leukopenia have beenobserved. Use cautiouslywith monoamine oxidaseinhibitors andserotonergic drugs.
Use in animals is reservedfor only drug-resistantinfections (e.g., MRSA) forwhich other drugs areineffective.
400 and 600 mgtablets. 20 mg/mLoral suspension.2 mg/ML injection.
10 mg/kg, q8–12h, po orIV.
Liothyronine (Cytomel)
Thyroid supplement.Liothyronine is equivalentto T
. 3
Adverse effects have notbeen reported (seeLevothyroxine sodium).
Doses of liothyronineshould be adjusted on thebasis of monitoring T
3
concentrations in patients.
60
μgtablets.
4.4
μg/kg q8h po. ForT
3
suppression test in cats:collect presample for T
4
and T
, administer 25 3
μg
q8h for 7 doses, thencollect postsamples for T
3
and T
4
after last dose.
Lokivetmab (Cytopoint) Caninized monoclonal
antibody against IL-31.Reduces pruritusassociated with allergicdermatitis.
Transient vomiting,diarrhea, lethargy.Treatment-inducedimmunogenicity mayreduce efficacy.
Not for use in cats
10, 20, 30, and40 mg single-usevials.
Dogs: 2 mg/kgsubcutaneously repeatedevery 4–8 weeks.
