Small Animal Dermatology, 3rd edition

APPENDIX B DRUG FORMULARY 801

Oclacitinib (Apoquel)

Janus kinase inhibitor.Reduces pruritusassociated with allergicdermatitis in dogs.

Vomiting, diarrhea,increased risk ofdemodicosis, pneumonia,persistent infection.

Approved for dogs 1 yearof age and older.

3.6, 5.4, and 16 mgtablets.

0.4–0.6 mg/kg q24h po.

Omeprazole (Prilosec)

Proton pump inhibitor.Omeprazole inhibitsgastric acid secretion byinhibiting the K

+/H

+

pump. Omeprazole ismore potent and longeracting than most availableantisecretory drugs. Usedfor treatment andprevention of GI ulcers.

Side effects have not beenreported in animals.

Drug

interactions

: Do not

administer with drugs thatdepend on stomach acidfor absorption (e.g.,ketoconazole).

Due to omeprazole’spotency and accumulationin gastric cells, infrequentadministration is possible.

20 mg capsules andequine paste.

Dog: 20 mg/dog q24h po(or 0.7 mg/kg q24h).Cat: 0.5–0.7 mg/kg q24hpo.

o,p

’-DDD

See Mitotane.

Orbifloxacin (Orbax)

Fluoroquinoloneantimicrobial. Samemechanism asenrofloxacin andciprofloxacin. Spectrumincludes staphylococci,gram-negative bacilli, andsome

Pseudomonas

.

May cause some nauseaand vomiting at highdoses. Avoid use in younganimals. Blindness in catshas not been reportedwithdoses

<

15 mg/kg/day.

Dose range is wide toaccount for susceptibilityof bacteria. Dosing shouldbe guided by susceptibilitytests.

5.7, 22.7, and68 mg tablets.

2.5–7.5 mg/kg q24h po.

Ormetoprim +sulfadimethoxine

Trimethoprim-like drugused in combination withsulfadimethoxine. (SeePrimor.)

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