544
Messenger RNAs (mRNAs) degradation,
OET (cont.)
regulation, 500
transcriptome analyses, 501
translated mRNAs, 501
ZGA, 507–508
Metaeutherians/non-placental mammals, 319
Metal-dependent protein phosphatases
(PPMs), 91
Methylated DNA immunoprecipitation
(MeDIP), 517
METRO pathway, 185
MicroRNA (miRNA)
AGO proteins, 496
degradation, 497, 498
dicer-deficient zebrafish oocytes, 497
genome-encoded posttranscriptional
regulators, 496
growing/fully grown oocytes, 497
maternal, 498
miR-202-5p, 497
molecular mechanism, 496–498
next-generation sequencing, 497
nonfunctional, 497
nuclear, 496
uncoupling, 497
zebrafish and Xenopus miRNA
analyses, 497
Microtubule actin cross-linking factor 1
(Macf1), 184, 193, 194
Midblastula transition (MBT), 101, 118, 408,
443–476, 489, 513, 517, 520
and MZT, 443
cell divisions, 443
chromatin architecture, 476
cleavage divisions, 442
cleavage divisions, embryonic (see
Embryonic cleavage divisions)
Drosophila, 442
large-scale zygotic transcription, 443
metazoan embryos initiate
development, 442
regulation, 443
regulation, zygotic transcription (see
Zygotic transcription, early embryo)
zygotic, 442
miR-290 family, 507
miR-430 family, 507
Mitochondria, 521–522
Mitochondrial cloud, 3, 180
Mitogen-activated protein kinase (MAPK), 9
Mitotic checkpoint complex (MCC), 90
Molecular Haeckels, 275
Monotremes, 318
Mosaic of regional processes, 265
M-phase, PP2A-B55 reactivation, 95
MS2 RNA-labeling system, 189
Musashi-dependent polyadenylation, 59N
NEM. See Endocytic Marginal cells (NEM)
Next-generation sequencing
small RNAs, 497
Nieuwkoop center, 212, 226, 238, 272,
330–331
Nieuwkoop model, 256
Nodal asymmetry, 273
Nodal morphogen gradient, 353–354
Nodal reaction-diffusion mechanism,
354–355
Nodal signaling pathway, 177
Non-surrounded nucleolus (NSN), 504,
512, 519
Non-teleost fish
blastopore, 322
Lampreys (Lampetra), 322
ray-finned fish, 322
NSN/SN transition, fully grown mouse
oocytes, 512
Nuclear cytoplasmic ratio, zygotic
transcription, 450, 470, 471
c-myc promoter, 469
DNA methylation, 471
Drosophila, 469
Geminin overexpression, 474
histone H3 and H4, 469
independent timer and activating factors,
472–474
N:C ratio model, 450
repressive factor, 468
and repressive mechanism, 469
short cell cycles
cleavage divisions, 470
high density of replication origins, 470
limitation, DNA replication, 470
rapid DNA replication, 471
Xenopus embryos, cycloheximide, 470
Smicl and RNAPII, 473
TBP, 473
tRNA, 469
Volume Ratio, 472
Xenopus embryos, 469
Nuclear envelope breakdown (NEBD), 89–91
Nuclear pore complexes (NPC), 196
Nuclear–cytoskeletal attachment, 125–126Index