97Chabala LD, Lester HA (1986) Activation of acetylcholine receptor channels by covalently bound
agonists in cultured rat myoballs. J Physiol 379:83–108
Chambers JJ, Banghart MR, Trauner D, Kramer RH (2006) Light-induced depolarization of neu-
rons using a modified Shaker K(+) channel and a molecular photoswitch. J Neurophysiol
96(5):2792–2796. doi:00318.2006 [pii] 10.1152/jn.00318.2006
Chanda B, Asamoah OK, Blunck R, Roux B, Bezanilla F (2005) Gating charge displacement in
voltage-gated ion channels involves limited transmembrane movement. Nature 436(7052):852–
- doi:nature03888 [pii] 10.1038/nature03888 [doi]
Chandrasekhar KD, Bas T, Kobertz WR (2006) KCNE1 subunits require co-assembly with K+
channels for efficient trafficking and cell surface expression. J Biol Chem 281(52):40015– - doi:M604398200 [pii] 10.1074/jbc.M604398200
Chen H, Kim LA, Rajan S, Xu S, Goldstein SA (2003) Charybdotoxin binding in the I(Ks)
pore demonstrates two MinK subunits in each channel complex. Neuron 40(1):15–23.
doi:S0896627303005701 [pii]
Chin JW (2014) Expanding and reprogramming the genetic code of cells and animals. Annu Rev
Biochem 83:379–408. doi:10.1146/annurev-biochem-060713-035737 [doi]
Demselben (1834) Ueber das Stickstoffbenzid. Annalen der Pharmacie 12(2–3):311–314.
doi:10.1002/jlac.18340120282
Doyle DA, Morais Cabral J, Pfuetzner RA, Kuo A, Gulbis JM, Cohen SL, Chait BT, MacKinnon R
(1998) The structure of the potassium channel: molecular basis of K+ conduction and selectiv-
ity. Science 280(5360):69–77
Fortin DL, Banghart MR, Dunn TW, Borges K, Wagenaar DA, Gaudry Q, Karakossian MH, Otis
TS, Kristan WB, Trauner D, Kramer RH (2008) Photochemical control of endogenous ion
channels and cellular excitability. Nat Methods 5(4):331–338. doi:nmeth.1187 [pii] 10.1038/
nmeth.1187
Gomez-Posada JC, Aivar P, Alberdi A, Alaimo A, Etxeberria A, Fernandez-Orth J, Zamalloa
T, Roura-Ferrer M, Villace P, Areso P, Casis O, Villarroel A (2011) Kv7 channels can func-
tion without constitutive calmodulin tethering. PLoS One 6(9):e25508. doi:10.1371/journal.
pone.0025508 PONE-D-11-09476 [pii]
Gorostiza P, Isacoff E (2007) Optical switches and triggers for the manipulation of ion channels
and pores. Mol Biosyst 3(10):686–704. doi:10.1039/b710287a
Gorostiza P, Volgraf M, Numano R, Szobota S, Trauner D, Isacoff EY (2007) Mechanisms of pho-
toswitch conjugation and light activation of an ionotropic glutamate receptor. Proc Natl Acad
Sci U S A 104(26):10865–10870. doi:0701274104 [pii] 10.1073/pnas.0701274104
Hartley G (1937) The Cis-form of Azobenzene. Nature 140:281. doi:10.1038/140281a0
He Y, Karpen JW (2001) Probing the interactions between cAMP and cGMP in cyclic nu-
cleotide-gated channels using covalently tethered ligands. Biochemistry 40(1):286–295.
doi:bi002014n [pii]
Hua Z, Kobertz WR (2013) Chemical derivatization and purification of peptide-toxins for prob-
ing ion channel complexes. Methods Mol Biol 995:19–30. doi:10.1007/978-1-62703-345-92
Hua Z, Lvov A, Morin TJ, Kobertz WR (2011) Chemical control of metabolically-engineered
voltage-gated K+ channels. Bioorg Med Chem Lett 21(17):5021–5024. doi:S0960-894X
(11)00569-5 [pii] 10.1016/j.bmcl.2011.04.099
Ibanez-Tallon I, Nitabach MN (2012) Tethering toxins and peptide ligands for modulation of neu-
ronal function. Curr Opin Neurobiol 22(1):72–78. doi:S0959-4388(11)00193-0 [pii] 10.1016/j.
conb.2011.11.003
Jarecki BW, Zheng S, Zhang L, Li X, Zhou X, Cui Q, Tang W, Chanda B (2013) Tethered spec-
troscopic probes estimate dynamic distances with subnanometer resolution in voltage-depen-
dent potassium channels. Biophys J 105(12):2724–2732. doi:S0006-3495(13)01238-1 [pii]
10.1016/j.bpj.2013.11.010 [doi]
Jensen MO, Jogini V, Borhani DW, Leffler AE, Dror RO, Shaw DE (2012) Mechanism of voltage
gating in potassium channels. Science 336 6078):229–233. doi:336/6078/229 [pii] 10.1126/
science.1216533
Bioreactive Tethers