Novel Chemical Tools to Study Ion Channel Biology (Advances in Experimental Medicine and Biology)

Index

153

A
Acetylcholine receptor (AChR), 7, 8, 16, 21,
22, 57, 122
Acid–base chemistry, 4
Azobenzene, 79, 82, 85, 86, 89, 90, 103

C
Chemical biology, 3
Conformational change, 3, 40–42, 56, 58, 63,
66, 102, 138
examination of, 57
voltage-driven, 57, 63
Conformational dynamics, 56, 70
Cysteine chemistry, 141
Cysteine modifications, 3, 40, 42

E
Evolved tRNA synthetase pairs, 125, 126

F
Fluorescent dye, 3, 58, 59, 69, 70

G
GABAA receptor, 30, 34, 38–41

I
Ion channel blockers, 92, 108
Ion channels, 1, 7, 27, 29
electrostatics of, 22

L
Ligand-gated, 43, 120, 136
Ligand-gated ion channels, 2, 6, 113
functional site-directed fluorometry in,
66, 67
PCLs of, 106–108
PTLs of, 109, 110

© Springer Science+Business Media New York 2015
C. Ahern, S. Pless (eds.), Novel Chemical Tools to Study Ion Channel Biology,
Advances in Experimental Medicine and Biology 869,
DOI 10.1007/978-1-4939-2845-3

Ligands, 1, 66, 77, 90

pharmacologically-active, 113

M

Membrane transporter, 25

Methanethiosulfonate (MTS), 27, 29, 30, 32,

40, 62

N

Nonsense suppression, 120, 133, 143

application of, 137, 138

in vivo, 122, 124, 125

O

Optical control, 86, 107, 114

Optochemical genetics, 102, 112

Optogenetics, 140, 141

P

Photochrome, 4, 102–104

definition of, 102

Photopharmacology, 102, 112

one-component, 104

Potassium channels, 43, 79, 137, 140, 141

Protein derivatization, 80

Protein semi-synthesis, 120

Proton transfer, 16, 17, 20

Q

Quaternary ammonium compounds, 40

S

Side chain protonation, 8

Single-molecule electrophysiology, 6

Site-directed fluorometry, 56–59, 61

application of, 68