Exercise for Cardiovascular Disease Prevention and Treatment From Molecular to Clinical, Part 1

80 1.2 Training Effects on Contractile Proteins Content The contractile proteins, like myosin and actin present inside the cardi ...

81 these studies are consistent with data from Soci and colleagues showing an increase in the ratio α/βMHC during long term swim ...

82 type of exercise training, temperature, cell isolation protocol, regional cardiac differences or stimulation frequency. Howev ...

83 cardiac isoform of SR Ca2+ ATPase (SERCA2a) and sarcolemmal extrusion via NCX (in forward mode) and to a lesser extent via th ...

84 sparks are local increase of Ca2+ elicited by synchronized opening of RyR2, at rest, without excitation by L-type Ca2+ channe ...

85 node electrophysiological remodeling. These authors also observed changes in transcripts of ion channels that participate in ...

86 particularly for Iss and Ik1 in both animal models and for Ikslow PI3Kα mouse model. Ito current density was not impacted by ...

87 support heart rate acceleration by the reduction of the APD. However, number of calcium and electrophysiological remodeling r ...

88 Kemi OJ, Haram PM, Loennechen JP et al (2005) Moderate vs. high exercise intensity: differential effects on aerobic fitness, ...

89 Wisloff U, Loennechen JP, Currie S et al (2002) Aerobic exercise reduces cardiomyocyte hypertrophy and increases contractili ...

90 Alekseev AE, Reyes S, Yamada S et al (2010) Sarcolemmal ATP-sensitive K(+) channels control energy expenditure determining b ...

© Springer Nature Singapore Pte Ltd. 2017 91 J. Xiao (ed.), Exercise for Cardiovascular Disease Prevention and Treatment, Advanc ...

92 1 Introduction Heart failure caused by ischemic cardiac diseases is a leading cause of death world- wide [ 1 , 2 ]. After the ...

93 To date, increasing evidence has confirmed that the adult mammalian heart had a certain degree of self-renewal [ 22 – 25 ]. D ...

94 investigation of CSCs, several additional and distinct CSC classes have been detected such as Sca-1 positive cells, Islet-1 p ...

95 [ 28 ]. Furthermore, the low level of cardiomyocytes proliferation under normal cir- cumstances could be increased in the bor ...

96 5 Exercise Induces Proliferation of Pre-existing Cardiomyocytes Increasing data have shown that endurance exercise can induce ...

97 After myocardial infarction or pressure overload, a large number of cardiomyo- cytes undergo apoptosis and necrosis, leading ...

98 strategies have been largely investigated in the treatment of myocardial ischemia and other cardiac diseases. However, low su ...

99 Acknowledgements This work was supported by the grants from National Natural Science Foundation of China (81570362, 91639101 ...