225
- Mendoza MC, Er EE, Blenis J (2011) The Ras-ERK and PI3K-mTOR pathways: cross-talk
and compensation. Trends Biochem Sci 36:320–328 - Saltiel AR, Kahn CR (2001) Insulin signalling and the regulation of glucose and lipid metab-
olism. Nature 414:799–806 - Zeng G, Nystrom FH, Ravichandran LV et al (2000) Roles for insulin receptor, PI3-kinase,
and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular
endothelial cells. Circulation 101:1539–1545 - Taniguchi CM, Kondo T, Sajan M et al (2006) Divergent regulation of hepatic glucose and
lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta. Cell Metab
3:343–353 - Fischer Y, Thomas J, Sevilla L et al (1997) Insulin-induced recruitment of glucose transporter
4 (GLUT4) and GLUT1 in isolated rat cardiac myocytes. Evidence of the existence of differ-
ent intracellular GLUT4 vesicle populations. J Biol Chem 272:7085–7092 - XL D, Edelstein D, Rossetti L et al (2000) Hyperglycemia-induced mitochondrial superoxide
overproduction activates the hexosamine pathway and induces plasminogen activator inhibi-
tor- 1 expression by increasing Sp1 glycosylation. Proc Natl Acad Sci U S A 97:12222–12226 - Nishikawa T, Edelstein D, XL D et al (2000) Normalizing mitochondrial superoxide produc-
tion blocks three pathways of hyperglycaemic damage. Nature 404:787–790 - Inoguchi T, Battan R, Handler E et al (1992) Preferential elevation of protein kinase C
isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differen-
tial reversibility to glycemic control by islet cell transplantation. Proc Natl Acad Sci U S A
89:11059–11063 - Igarashi M, Wakasaki H, Takahara N et al (1999) Glucose or diabetes activates p38 mitogen-
activated protein kinase via different pathways. J Clin Investig 103:185–195 - Hattori Y, Hattori S, Sato N et al (2000) High-glucose-induced nuclear factor kappaB activa-
tion in vascular smooth muscle cells. Cardiovasc Res 46:188–197 - Way KJ, Isshiki K, Suzuma K et al (2002) Expression of connective tissue growth factor is
increased in injured myocardium associated with protein kinase C beta2 activation and dia-
betes. Diabetes 51:2709–2718 - Yamaguchi H, Igarashi M, Hirata A et al (2004) Altered PDGF-BB-induced p38 MAP
kinase activation in diabetic vascular smooth muscle cells: roles of protein kinase C-delta.
Arterioscler Thromb Vasc Biol 24:2095–2101 - Tabit CE, Shenouda SM, Holbrook M et al (2013) Protein kinase C-beta contributes to impaired
endothelial insulin signaling in humans with diabetes mellitus. Circulation 127:86–95 - Wakasaki H, Koya D, Schoen FJ et al (1997) Targeted overexpression of protein kinase C beta2
isoform in myocardium causes cardiomyopathy. Proc Natl Acad Sci U S A 94:9320–9325 - Inoguchi T, Li P, Umeda F et al (2000) High glucose level and free fatty acid stimulate reac-
tive oxygen species production through protein kinase C-dependent activation of NAD(P)H
oxidase in cultured vascular cells. Diabetes 49:1939–1945 - Chen F, Yu Y, Haigh S et al (2014) Regulation of NADPH oxidase 5 by protein kinase C
isoforms. PLoS One 9:e88405 - Connelly KA, Kelly DJ, Zhang Y et al (2009) Inhibition of protein kinase C-beta by
ruboxistaurin preserves cardiac function and reduces extracellular matrix production in dia-
betic cardiomyopathy. Circ Heart Fail 2:129–137 - Loganathan R, Novikova L, Boulatnikov IG et al (2012) Exercise-induced cardiac perfor-
mance in autoimmune (type 1) diabetes is associated with a decrease in myocardial diacylg-
lycerol. J Appl Physiol (1985) 113:817–826 - Gonzalez RG, Barnett P, Aguayo J et al (1984) Direct measurement of polyol pathway activ-
ity in the ocular lens. Diabetes 33:196–199 - Iwata K, Nishinaka T, Matsuno K et al (2007) The activity of aldose reductase is elevated in
diabetic mouse heart. J Pharmacol Sci 103:408–416 - Tang WH, Cheng WT, Kravtsov GM et al (2010) Cardiac contractile dysfunction during
acute hyperglycemia due to impairment of SERCA by polyol pathway-mediated oxidative
stress. Am J Physiol Cell Physiol 299:C643–C653
12 Exercise Amaliorates Metabolic Disturbances and Oxidative Stress in Diabetic...