229
- Husain K, Hazelrigg SR (2002) Oxidative injury due to chronic nitric oxide synthase inhibi-
tion in rat: effect of regular exercise on the heart. Biochim Biophys Acta 1587:75–82 - Kleindienst A, Battault S, Belaidi E et al (2016) Exercise does not activate the β3 adrenergic
receptor-eNOS pathway, but reduces inducible NOS expression to protect the heart of obese
diabetic mice. Basic Res Cardiol 111:40 - Harzand A, Tamariz L, Hare JM (2012) Uric acid, heart failure survival, and the impact of
xanthine oxidase inhibition. Congest Heart Fail 18:179–182 - Amado LC, Saliaris AP, Raju SV et al (2005) Xanthine oxidase inhibition ameliorates
cardiovascular dysfunction in dogs with pacing-induced heart failure. J Mol Cell Cardiol
39:531–536 - Rajesh M, Mukhopadhyay P, Batkai S et al (2009) Xanthine oxidase inhibitor allopurinol
attenuates the development of diabetic cardiomyopathy. J Cell Mol Med 13:2330–2341 - Gao X, Xu Y, Xu B et al (2012) Allopurinol attenuates left ventricular dysfunction in rats with
early stages of streptozotocin-induced diabetes. Diabetes Metab Res Rev 28:409–417 - Suzuki H, Kayama Y, Sakamoto M et al (2015) Arachidonate 12/15-lipoxygenase-induced
inflammation and oxidative stress are involved in the development of diabetic cardiomyopa-
thy. Diabetes 64:618–630 - Faria A, Persaud SJ (2016) Cardiac oxidative stress in diabetes: mechanisms and therapeutic
potential. Pharmacol Ther 172:50. doi:10.1016/j.pharmthera.2016.11.013 - Wautier MP, Chappey O, Corda S et al (2001) Activation of NADPH oxidase by AGE
links oxidant stress to altered gene expression via RAGE. Am J Physiol Endocrinol Metab
280:E685–E694 - Christ SE, Moffitt AJ, Peck D et al (2013) The effects of tetrahydrobiopterin (BH4) treatment
on brain function in individuals with phenylketonuria. Neuroimage Clin 3:539–547 - Hou J, Zheng D, Fung G et al (2016) Mangiferin suppressed advanced glycation end products
(AGEs) through NF-κB deactivation and displayed anti-inflammatory effects in streptozoto-
cin and high fat diet-diabetic cardiomyopathy rats. Can J Physiol Pharmacol 94:332–340 - Gu Q, Wang B, Zhang XF et al (2014) Contribution of receptor for advanced glycation end
products to vasculature-protecting effects of exercise training in aged rats. Eur J Pharmacol
741:186–194 - Santilli F, Vazzana N, Iodice P et al (2013) Effects of high-amount-high-intensity exercise on
in vivo platelet activation: modulation by lipid peroxidation and AGE/RAGE axis. Thromb
Haemost 110:1232–1240 - Fisher-Wellman KH, Mattox TA, Thayne K et al (2013) Novel role for thioredoxin reductase-
2 in mitochondrial redox adaptations to obesogenic diet and exercise in heart and skeletal
muscle. J Physiol 591:3471–3486 - Claudio ER, Almeida SA, Mengal V et al (2017) Swimming training prevents coronary endo-
thelial dysfunction in ovariectomized spontaneously hypertensive rats. Braz J Med Biol Res
50:e5495 - Hyatt HW, Smuder AJ, Sollanek KJ et al (2016) Comparative changes in antioxidant enzymes
and oxidative stress in cardiac, fast twitch and slow twitch skeletal muscles following endur-
ance exercise training. Int J Physiol Pathophysiol Pharmacol 8:160–168 - Conti FF, Brito Jde O et al (2015) Positive effect of combined exercise training in a model of
metabolic syndrome and menopause: autonomic, inflammatory, and oxidative stress evalua-
tions. Am J Physiol Regul Integr Comp Physiol 309:R1532–R1539 - Tan Y, Ichikawa T, Li J et al (2011) Diabetic downregulation of Nrf2 activity via ERK con-
tributes to oxidative stress-induced insulin resistance in cardiac cells in vitro and in vivo.
Diabetes 60:625–633 - Horie M, Warabi E, Komine S et al (2015) Cytoprotective role of Nrf2 in electrical pulse
stimulated C2C12 myotube. PLoS One 10:e0144835 - Merry TL, Ristow M (2016) Nuclear factor erythroid-derived 2-like 2 (NFE2L2, Nrf2) medi-
ates exercise-induced mitochondrial biogenesis and antioxidant response in mice. J Physiol
594:5195–5207
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