267
- Smith CL, Baek ST, Sung CY et al (2011) Epicardial-derived cell epithelial-tomesenchymal
transition and fate specification require PDGF receptor signaling. Circ Res 108(12):e15–e26 - Ivey MJ, Tallquist MD (2016) Defining the cardiac fibroblast. Circ J 80:2269–2276
- Gabbiani G, Ryan G, Majno G (1971) Presence of modified fibroblasts in granulation tissue
and their possible role in wound contraction. Experientia 27:549–550 - Lagace R, Delage C, Boutet M (1974) Light and electron microscopic study of cellular prolif-
eration in carcinoid heart disease. Recent Adv Stud Card Struct Metabol 10:605–616 - Kischer C, Shetlar M (1978) Electron microscopic studies of connective tissue repair after
myocardial injury. Tex Rep Biol Med 39:357–369 - van Putten S, Shafieyan Y, Hinz B (2016) Mechanical control of cardiac myofibroblasts. J Mol
Cell Cardiol 93:133–142 - Furtado MB, Nim HT, Boyd SE et al (2016) View from the heart: cardiac fibroblasts in devel-
opment, scarring and regeneration. Development 143:387–397 - Mehal WZ, Iredale J, Friedman SL (2011) Scraping fibrosis: expressway to the core of fibrosis.
Nat Med 17:552–553 - Frangogiannis NG (2004) Chemokines in the ischemic myocardium: from inflammation to
fibrosis. Inflamm Res 53:585–595 - Frangogiannis NG (2012) Regulation of the inflammatory response in cardiac repair. Circ Res
110:159–173 - Furtado MB, Costa MW, Pranoto EA et al (2014) Cardiogenic genes expressed in cardiac
fibroblasts contribute to heart development and repair. Circ Res 114:1422–1434 - Davis J, Molkentin JD (2014) Myofibroblasts: trust your heart and let fate decide. J Mol Cell
Cardiol 70:9–18 - Tan M, Luo H, Lee S et al (2011) Identification of 67 histone marks and histone lysine croto-
nylation as a new type of histone modification. Cell 146:1016–1028 - Bradbury EM (1992) Reversible histone modifications and the chromosome cell cycle. Bio
Essays 14:9–16 - Shiio Y, Eisenman RN (2003) Histone sumoylation is associated with transcriptional repres-
sion. Proc Natl Acad Sci U S A 100:13225–13230 - Xie Z, Dai J, Dai L et al (2012) Lysine succinylation and lysine malonylation in histones. Mol
Cell Proteomics 11:100–107 - Stratton MS, McKinsey TA (2016) Epigenetic regulation of cardiac fibrosis. Mol Cell Cardiol
92:206–213 - Neubauer S (2007) The failing heart — an engine out of fuel. NEJM 356:1140–1151
- Ono K, Kuwabara Y, Han Y (2011) MicroRNAs and cardiovascular diseases. FEBS
J 278(10):1619–1633 - Latronico MVG, Catalucci D, Condorelli G (2007) Emerging role of microRNAs in cardiovas-
cular biology. Circ Res 101:1225–1236 - Sullivan MJ, Higginbotham MB, Cobb FR (1988) Exercise training in patients with severe left
ventricular dysfunction: hemodynamic and metabolic effects. Circulation 78:506–515 - Hambrecht R, Gielen S, Linke A et al (2000) Effects of exercise training on left ventricular
function and peripheral resistance in patients with chronic heart failure: a randomised trial.
JAMA 283:3095–3101 - Giannuzzi P, Temporelli PL, Corra U et al (2003) Antiremodeling effect of long-term exercise
training in patients with stable chronic heart failure: results of the exercise in left ventricular
dysfunction and chronic heart failure (ELVD-CHF) trial. Circulation 108:554–559 - McMullen JR, Amirahmadi F, Woodcock EA et al (2007) Protective effects of exercise and
phosphoinositide 3-kinase(p110) signaling in dilated and hypertrophic cardiomyopathy. Proc
Natl Acad Sci U S A 104:612–617 - Xu X, Wan W, Powers AS et al (2008) Effects of exercise training on cardiac function and
myocardial remodeling in post myocardial infarction rats. J Mol Cell Cardiol 44:114–122 - Wilson MG, Ellison GM, Cable NT (2015) Basic science behind the cardiovascular benefits of
exercise. Heart 101:758–765
14 Cardiac Fibrosis: The Beneficial Effects of Exercise in Cardiac Fibrosis