Chromogranins from Cell Biology to Physiology and Biomedicine

216 peptides based on potential cleavage sites at paired basic residues in CgA as shown in Fig. 2B (Koshimizu et al. 2011b; Loh ...

217 purified and sequenced serpinin from mouse. Of note is the sequence of bovine and human serpinin differs by 4 amino acids fr ...

218 secretory granules at the tips of processes and poised for secretion. pGlu-serpinin was found to be secreted in a stimulated ...

219 4.2 Expression and Localization of p-Glu Serpinin in the Central Nervous System Studies on the expression of serpinin and pG ...

220 in the motor activities, by carrying information from the primary motor cortex to the ipsilateral pontine nucleus in the ven ...

221 than serpinin (Koshimizu et  al. 2011b). It was demonstrated that the enhanced expression of PN-1 by serpinin was mediated t ...

222 subsequently replenished. Our studies found that secreted serpinin and pGlu-ser- pinin act as a signal to drive granule biog ...

223 stress. Neurons treated with 10 nM pGlu-serpinin in the presence of H 2 O 2 showed no difference in MAP 2 (a neuronal marker ...

224 7 Anti-Angiogenesis Effect of Serpinin-RRG The effect of human serpinin peptides on angiogenesis were assayed using the chic ...

225 0 0nM 10nM 100nM 0.1nM 0nM+H2O2 10nM+H2O2 100nM+H2O2 0.1nM+H2O2 1nM 1nM+H2O2 20 40 60 80 100 120 140 160 180 Serpinin pGlu-S ...

226 CgA(1–400) and CgA(1–409) which is CgA minus the serpinin sequence]. However, the CgA C-terminal peptides, (serpinin, pGlu-s ...

227 8 Conclusions The serpinin family of peptides is the newest set of biologically active peptides found to be derived from pro ...

228 Kim T, Loh YP (2006) Protease nexin-1 promotes secretory granule biogenesis by preventing granule protein degradation. Mol B ...

© Springer International Publishing AG 2017 229 T. Angelone et al. (eds.), Chromogranins: from Cell Biology to Physiology and Bi ...

230 1 Introduction Pancreastatin (PST) is a regulatory peptide with multiple effects on the general metabolism. And even though ...

231 even higher when the C-terminal fragment is compared. This is not surprising considering that it is the biological active pa ...

232 2 Biological Effects As explained above, pancreastatin is an important mediator in many biological functions such as autocri ...

233 2.1 Effects on Glandular Secretions 2.1.1 Endocrine Secretion PST Inhibits Glucose Stimulated Insulin Secretion in Endocrine ...

234 2.1.2 Exocrine Secretion PST Stimulates Gastric Secretion Despite of some in vitro studies in isolated parietal rabbit cells ...

235 2.3 PST Increase Hepatic Glycogen Catabolism and Inhibits Insulin-Stimulated Glucose Uptake In vivo, PST seems to exert dire ...