Chromogranins from Cell Biology to Physiology and Biomedicine

236 Regarding the lipid metabolism, PST causes a threefold rise of free fatty acids and glycerol release, although this effect i ...

237 PLC inhibition, stimulated by PST, probably mediating a negative feed-back of PST signaling (Sanchez-Margalet and Goberna 19 ...

238 gluconeogenesis, by the inhibition of the insulin signaling (Gayen et  al. 2009 ; Valicherla et al. 2013 ). All these data s ...

239 PST receptor could belong to the G protein coupled receptors family (Sanchez- Margalet and Santos-Alvarez 1997 ). Therefore, ...

240 insulin tyrosine kinase signaling: such as the tyrosine phosphorylation of insulin receptor substrate-1/2 (IRS-1/2) or the b ...

2 41 of insulin signaling (Arap et al. 2004 ; Delpino and Castelli 2002 ; Misra et al. 2006 ; Misra and Pizzo 2010 ; Shani et  a ...

242 et al. 2010 ). High affinity PST receptors have been characterized by our group and their signal transduction in liver and a ...

243 PST-297S than PST 287  K, and this one, in turn, higher than WT-PST.  These differences in secondary structure, have a direc ...

244 Cohn DV, Zangerle R, Fischer-Colbrie R, Chu LL, Elting JJ, Hamilton JW, Winkler H (1982) Similarity of secretory protein I f ...

245 Hakanson R, Ding XQ, Norlen P, Chen D (1995) Circulating pancreastatin is a marker for the enterochromaffin-like cells of th ...

246 Sanchez-Margalet V, Goberna R (1994a) Pancreastatin activates pertussis toxin-sensitive guanylate cyclase and pertussis toxi ...

247 Shani G, Fischer WH, Justice NJ, Kelber JA, Vale W, Gray PC (2008) GRP78 and Cripto form a complex at the cell surface and c ...

© Springer International Publishing AG 2017 249 T. Angelone et al. (eds.), Chromogranins: from Cell Biology to Physiology and Bi ...

250 VMAT Vesicular mono-amine transporter VNUT Vesicular nucleotide transporter WT Wild type animals Chromogranins are the main ...

251 derivatives (Taupenot et  al. 2003 ; Montero-Hadjadje et  al. 2008 ; Zhao et  al. 2009 ; Helle 2004 ). (iv) To facilitate th ...

252 (Videen et  al. 1992 ), and depending on the granin type, chromogranins can bind ≈50 mol Ca2+ per mol with a Kd of 1.5–4 mM ...

253 CgA-KO chromaffin cells. Conversely, the overexpression of CgA causes, both in PC12- and in HEK293-cells, a drastic increase ...

254 1 Catecholamine Exocytosis in the Absence of Chromogranin B The absence of CgB in CgB-KO mice was confirmed by immunohistoch ...

255 2 Catecholamine Exocytosis in the Absence of Chromogranins A and B The generation of double CgA&B-KO mice allowed us to ...

256 matrix (Diaz-Vera et al. 2012 ). The large vesicular size is likely the result of osmotic decompensation and it may explain ...