Computational Methods in Systems Biology
Explaining Response to Drugs Using Pathway Logic 251 2.1 PL Concepts and Reasoning Tools Curation Inference Reasoning Datums Rul ...
252 C. Talcott and M. Knapp used in [ 10 ] detects Akt1, Akt2, and Akt3. We cannot determine whether the increase in the level o ...
Explaining Response to Drugs Using Pathway Logic 253 mutations). Then, using PLA, we do a forward collection from this initial s ...
254 C. Talcott and M. Knapp Fig. 2.Three principles be explained by a PL model because they are caused by things other than sign ...
Explaining Response to Drugs Using Pathway Logic 255 The number ofexperimental replicates is the number of times the procedure ...
256 C. Talcott and M. Knapp used in the experiment. Subsequent literature search revealed solid evidence for proposed mechanisms ...
Explaining Response to Drugs Using Pathway Logic 257 Mek1-act-phos!SMANS@CLc 014c 431c Ybx1@CLc 3826c Ybx1-phos!S102@CLc Axin1@C ...
258 C. Talcott and M. Knapp and Temsirolimus in some detail, and briefly summarize the results for the other three drugs. Recall ...
Explaining Response to Drugs Using Pathway Logic 259 Eif4ebp1-phos!S65,Eif4ebp1-phos!T37,Gsk3b-phos!S9,Gsk3s-phos!SFAE, Rps6-pho ...
260 C. Talcott and M. Knapp experiments giving evidence, or because they have not yet been curated. It is also possible that the ...
Explaining Response to Drugs Using Pathway Logic 261 Make a table with columns corresponding to the negatively changed occur- r ...
262 C. Talcott and M. Knapp Now we check whether blocking this pair of occurrences is consistent with the measured response to S ...
Explaining Response to Drugs Using Pathway Logic 263 under a different intervention (inhibition of the kinase mTOR). While some ...
264 C. Talcott and M. Knapp References Aksoy, B.A.: BioPax prior information provider (PERA) (2017).http://bit.ly/bp prior. Acc ...
Automated Property Synthesis of ODEs Based Bio-pathways Models Jun Zhou1(B), R. Ramanathan^1 , Weng-Fai Wong^1 , and P.S. Thiaga ...
266 J. Zhou et al. from these models is appealing for at least two reasons. First, the synthesized specifications can point to m ...
Automated Property Synthesis of ODEs Based Bio-pathways Models 267 ofψ̂. Subsequently, theloss functioncomputes the loss, and re ...
268 J. Zhou et al. notion for stochastic systems and then uses this notion to optimize chosen con- trol parameters of a stochast ...
Automated Property Synthesis of ODEs Based Bio-pathways Models 269 finite set of atomic propositions. BLTL formulas are then def ...
270 J. Zhou et al. Table 1.Basic templates No. Template Description 1 p 1 ∧F≤t^1 G≤t^2 p 2 wherep 1 :( 1 ≤x≤u 1 ) p 2 :( 2 ≤x≤ ...
«
8
9
10
11
12
13
14
15
16
17
»
Free download pdf