Multiphase Bioreactor Design

Table 14.1 Commerical/near-commercial processes

involving plant cell suspension cultures

Product
(system)

Application Company Scale/Configuration Operating

details

Reference

Berberine
(Coptis
japonica)

medicinal Mitsui

Chemicals

Inc., Japan

6000 L STR fed-batch

perfusion

2-stage

continuous

(not in

production)

Fujita

(1988b)

Matsubara

& Fujita

(1991)

Takahashi

(1999)

Ginseng
(Panax
ginseng)

health food additive Nitto Denko

Corporation,

Japan

20 000 L, 25 000 L

STR

pitched-

blade disk

turbine

batch

Hibino

(1999)

Hibino &

Ushiyama

(1999)

Paclitaxel—
Genexol®
(Taxus spp.)

medicinal Samyang

Genex

Corporation,

Korea

32 000 L STR Kang

(1999)

Paclitaxel—
Taxol® (Taxus
spp.)

medicinal Phyton Inc,

USA/Germany

75 000 L STR Venkat

(1996)

Paclitaxel
(Taxus spp.)

medicinal Mitsui

Chemical Inc.,

Japan

200 L STR Takahashi

(1999)

Plant
polysaccharides

food/pharmaceutical/

cosmetic additive

Cooperative

Research

Centre for

Industrial

Plant

Biopolymers

(CRCIPB),

Australia

10 000 L STR

1000 L ALR

axial flow

impeller

semi-

continuous

mode

CRCIPB

(1998)

Doran

(2000)

Plant
polysaccharides
(Polianthes
tuberosa)

cosmetics Kao

Corporation,

Japan

4000 L, 10 000 L

STR with draft tube

fed-batch

or

continuous

mode

Takei et

al. (1995)

Otsuji

(1999)

Shikonin
(Lithospermum
erythrorhizori)

cosmetics Mitsui

Chemicals

Inc., Japan

200 L, 750 L STR two-stage

batch

Fujita

(1988a)

Takahashi

& Fujita

(1991)

Bioreactor design for plant cell suspension cultures 419