Organ Regeneration Based on Developmental Biology

130 they survived (Fig. 7.6b). These findings indicate that saliva secretion from bioengi- neered salivary glands can improve th ...

131 References Aframian DJ, Palmon A (2008) Current status of the development of an artificial salivary gland. Tissue Eng Part B ...

132 Kishi T, Takao T, Fujita K, Taniguchi H (2006) Clonal proliferation of multipotent stem/progenitor cells in the neonatal and ...

133 Sasano T, Satoh-Kuriwada S, Shoji N, Sekine-Hayakawa Y, Kawai M, Uneyama H (2010) Application of umami taste stimulation to ...

© Springer Nature Singapore Pte Ltd. 2017 135 T. Tsuji (ed.), Organ Regeneration Based on Developmental Biology, DOI 10.1007/978 ...

136 8.1 Introduction Regenerative medicine to restore organ function has been developed as realizable therapy due to perpetual a ...

137 the lacrimal glands has been required to redeem biological tear fluids (Hirayama et al. 2015 ). This review summarized the p ...

138 as an invagination of the conjunctival epithelium to mesenchymal sac at the tempo- ral region of the eye and then starts to ...

139 Branching morphogenesis Cell proliferatioBud and acini formationExtracellular matrixremodeling n Mesenchymal proliferation&a ...

140 conjunctival epithelium into the lacrimal gland epithelium bud (Grindley et  al. 1995 ; Hill et  al. 1992 ). The temporal pe ...

141 been trialed in human (Sant’ Anna et  al. 2012 ; Marinho et  al. 2010 ). The results seem promising preliminary; however, a ...

142 lacrimal glands has been established, thanks to the development of tissue engineer- ing using 3D cell manipulation procedure ...

143 a b Harderiangland germ Bioengineered Day 0 Day 3 Day 5 Lacrimalgland germ In vitro culture Day 30 after transplantation c D ...

14 4 These play an important role for increasing tear stability, wound healing, and anti- bacterial effects (Mishima 1965 ; Chen ...

145 (Tiwari et al. 2012 ). Another demand for regenerating the lacrimal gland would be the use of available cell sources includi ...

146 References Ahrens K, Schlosser G (2005) Tissues and signals involved in the induction of placodal Six1 expression in Xenopus ...

147 Goto E, Dogru M, Sato EA, Matsumoto Y, Takano Y, Tsubota K (2011) The sparkle of the eye: the impact of ocular surface wetne ...

148 assessed with ultra-high resolution optical coherence tomography. Acta Ophthalmol 93(5):439– doi:10.1111/aos.12647 Kojima T ...

149 Ohashi Y, Dogru M, Tsubota K (2006) Laboratory findings in tear fluid analysis. Clin Chim Acta Int J Clin Chem 369(1):17–28. ...

150 tears in patients with moderate dry eye disease. Cornea 34(4):421–426. doi:10.1097/ ICO.0000000000000358 Seal DV, McGill JI, ...