Imaging in Stem Cell Transplant and Cell-based Therapy

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Table 8.1

Functional effect of stem cell therapy and imaging techniques used

Study

Setting

Route of delivery

LVEF/technique used

Myocardial perfusion/technique used

Infarct size/technique used

Myocardial viability/technique used

TOPCARE-

AMI

AMI

Intracoronary

> (9.3%)/LV angiography, cine MRI

Decreased perfusion defect/TI-SPECT

Decreased/CMR

Increased F18-FDG around infarction/F18-FDG PET

BOOST

AMI

Intracoronary

No change/cine MRI

NA

No change/CMR

NA

Chen et al.

AMI

Intracoronary

>(18.0%)/LV angiography

NA

Decreased/LV angiography

Increased F18-FDG around infarction/F18-FDG PET

Janssens et al.

AMI

Intracoronary

No change/cine MRI

No change in perfusion defect/PET

Decreased/CMR

No change/ PET

Bartunek et al

AMI

Intracoronary

>(7%)/LV angiography

Decreased perfusion defect/Tc-SPECT

NA

Increased F18-FDG around infarction/F18-FDG PET

ASTAMI

AMI

Intracoronary

No change/gated SPECT, MRI, ECHO

NA

No change/CMR

NA

TOPCARE-

CHD

CMI

Intracoronary

> (2.9%)/LV angiography

NA

No change/CMR

NA

IACT

CMI

Intracoronary

>(8.0%)/LV angiography

Decreased perfusion defect/Tc-SPECT

Decreased/LV angiography

Increased F18-FDG around infarction/F18-FDG PET

Fuchs et al.

AP

Intramyocardial

No change/echo

Increased stress perfusion/TI-SPECT

NA

NA

Beeres et al.

AP

Intramyocardial

>(4.0%)/gated SPECT, cine MRI

Decreased extent of ischemial/Tc SPECT

No change/CMR

No change in viability/F18-FDG SPECT

Perin et al.

HF

Intramyocardial

No change/LV angiography, Echo

No change in perfusion defect/Tc SPECT

NA

Improvement in injected segments/electromechanical mapping

(continued)

8 Cardiac Imaging and Stem Cell Transplantation