Revival: Biological Effects of Low Level Exposures to Chemical and Radiation (1992)
64 BIOLOGICAL EFFECTS OF LOW LEVEL EXPOSURES Table 4.1. Amplification of Lethal Effects of Several Halomethanes by Dietary Expos ...
BIPHASIC DOSE-RESPONSE RELATIONSHIPS 65 Figure 4.1. Structures of chlordecone, mirex, photomirex, and phenobarbital. Chlordecone ...
66 BIOLOGICAL EFFECTS OF LOW LEVEL EXPOSURES Figure 4.2. Structures of carbon tetrachloride, bromotrichloromethane, and chlorofo ...
BIPHASIC DOSE-RESPONSE RELATIONSHIPS 67 Figure 4.3. Structure of 1,1,2-trichloroethylene, bromobenzene, bromoform, and dibromodi ...
68 BIOLOGICAL EFFECTS OF LOW LEVEL EXPOSURES Table 4.4. Candidate Mechanisms of Chlordecone Amplification of Halomethane Toxicit ...
BIPHASIC DOSE-RESPONSE RELATIONSHIPS 69 Figure 4.4. Proposed mechanism for the highly amplified interactive toxicity of chlordec ...
70 BIOLOGICAL EFFECTS OF LOW LEVEL EXPOSURES the same mechanisms of bioactivation of CC1 4 and lipid peroxidation (Fig ure 4.4) ...
BIPHASIC DOSE-RESPONSE RELATIONSHIPS 71 of liver injury 111 would be consistent with the significant loss of biochemical homeost ...
72 BIOLOGICAL EFFECTS OF LOW LEVEL EXPOSURES Figure 4.5. Proposed mechanism for phenobarbital-induced potentiation of CCI4-hepat ...
BIPHASIC DOSE-RESPONSE RELATIONSHIPS 73 txL/kg) and returned to basal level by 6 hr.84 Serum transaminases in these rats undergo ...
74 BIOLOGICAL EFFECTS OF LOW LEVEL EXPOSURES Table 4.5. Evidence in Support of the Proposed Mechanism Experimental Manipulation ...
BIPHASIC DOSE-RESPONSE RELATIONSHIPS 75 the form of stimulated early-phase cell division and tissue repair. The higher dose clea ...
76 BIOLOGICAL EFFECTS OF LOW LEVEL EXPOSURES Table 4.6. High Sensitivity of Mongolian Gerbils to Halomethane Toxicity Contrasted ...
BIPHASIC DOSE-RESPONSE RELATIONSHIPS 77 also underscore the importance of the biological hormetic response in deter mining the ...
78 BIOLOGICAL EFFECTS OF LOW LEVEL EXPOSURES Selective Ablation of the Early-Phase Hormetic Response by Colchicine Finally, the ...
BIPHASIC DOSE-RESPONSE RELATIONSHIPS 79 observation also provides very substantial and convincing experimental evi dence for th ...
80 BIOLOGICAL EFFECTS OF LOW LEVEL EXPOSURES injury, leading to massive coagulative hepatic necrosis, is observed.214-16 Likewis ...
BIPHASIC DOSE-RESPONSE RELATIONSHIPS 81 with the unablated hepatocellular proliferation and tissue repair.8385 Delayed hepatocel ...
82 BIOLOGICAL EFFECTS OF LOW LEVEL EXPOSURES toxicity is not at all increased in gerbils by prior exposure to phenobarbital in s ...
BIPHASIC DOSE-RESPONSE RELATIONSHIPS 83 nisms between these strains could account for the strain differences in the ultimate tox ...
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