TEA, carnitine, quinidine,
verapamil
SLC22A5
OCTN2, CT1 Kidney, skeletal
muscle, prostate,lung, heart, pancreas,small intestine, liver
Small organic cations
TEA, cimetidine,
acetylcholine, choline,serotonine, quinidine,verapamil
Na
+
dependent: carnitine,
phaloridine
Na
+
independent: verapamil,
quinidine, TEA
SLC22A6
OAT1
Kidney, brain
Organic anions.Although cimetidine is an
organic cation, it is asubstrate that is recognizedby both organic cation andanion transporters. PAH,methotrexate, estrone sulfate,prostaglandin, DHEAS
SLC22A7
OAT2
Liver, kidney
SLC22A8
OAT3
Kidney, brain
SLC29A1
ENT1
Ubiquitous,
cancer cells
Nucleosides and
nucleoside analogues
Nitrobenzylthioinosine
and dipyridamolefor ENT1
Facilitated
transport
Adenosine, uridine,
inosine
SLC29A2
ENT2
Ubiquitous,
cancer cells
SLC28A1 CNT1
Liver, kidney,
intestine, brain
Purine nucleosides,
uridine
Na
+
free buffer
Na
+
dependent
(continued
)
145