Drug Metabolism in Drug Design and Development Basic Concepts and Practice

0

2

4

6

8

10

12

14

0 10 20 30 40 50 60 70 80

Rat

Dog

Monkey

Human

Total radioactivity (

mg

• muraglitazar equivalent/g)

Plasma collection time (h)

0

2

4

6

8

10

12

0 20 40 60 80 100

Rat

Dog

Monkey

Human

Muraglitazar concentration (

m/mL

)

Plasma collection time (h)

(A)

(B)

FIGURE 18.1 Total plasma radioactivity and muraglitazar concentration vs. time
profiles following a single administration of [^14 C]muraglitazar in rats (11 mg/kg), dogs
(1.9 mg/kg), monkeys (2 mg/kg), and humans (10 mg).

DATA PRESENTATION USING METABOLISM OF [^14 C]MURAGLITAZAR 589