7 Caspase targets 44
8 Function of individual caspases 45
Chapter 3 Making sense of the Bcl-2 family of apoptosis regulators
Loralee Haughn and David Hockenbery49
1 Introduction 49
2 Internecine warfare or private agendas 49
3 Location, location, location 63
4 A finger in every pot 67
5 Specialists or generalists? 68
6 Summary 69
Chapter 4 Functional domains in apoptosis proteins
Kay Hofmann71
1 Introduction 71
2 Death ligands and receptors 74
3 Adapter domains 78
4 Caspases and inhibitors 88
5 Other important domains 91
6 A domain-centric view of apoptosis 94Section II Cell Biology of Apoptosis
Chapter 5 The role of the endoplasmic reticulum in apoptosis
David G.Breckenridge and Gordon C.Shore97
1 Introduction 97
2 ER stress-induced apoptosis 98
3 Regulation of mitochondrial apoptosis by ER Ca2+ signals 107
4 Other ER regulators of apoptosis 114
5 Concluding remarks 118
Chapter 6 Mitochondria in apoptosis induction
Bruno Antonsson121
1 Introduction 121
2 The mitochondria 121v