Devita, Hellman, and Rosenberg's Cancer

LWBK1006-12 LWW-Govindan-Review November 24, 2011 11:21

Chapter 12•Cancer Prevention 137

Question 12.10. Which of the following statements regardingBRCAmutations is false?

A. The lifetime risk of ovarian cancer increases to 15% to 25% in

BRCA2 mutation carriers.

B. The frequency ofBRCA mutation carriers in Ashkenazi Jewish

population is approximately 2.5%.

C. BRCA2-associated ovarian cancer occurs at younger age compared

to sporadic cases.

D. BRCA1 is mutated more often thanBRCA2 in women with here-

ditary ovarian cancer.

Question 12.11. Which of the following statements regarding familial adenomatous poly-

posis (FAP) is FALSE?

A. The development of colorectal cancer is inevitable in the absence of

colectomy.

B. It is characterized by the presence of 100 or more adenomatous polyps

in the colorectum.

C. It accounts for approximately 5% of the colorectal cancer cases.

D. It is an autosomal-dominant disorder.

Question 12.12. What is the best treatment of a patient with FAP presenting with approx-

imately 300 colorectal polyps and 15 rectal adenomas?

A. Observation

B. Total proctocolectomy with permanent ileostomy (TPC)

C. Proctocolectomy with ileal pouch-anal anastomosis (IPAA)

D. Total colectomy with ileorectal anastomosis (IRA)

Question 12.13. Which of the following does not represent an indication for microsatel-

lite instability (MSI) testing in patients with suspected hereditary non-

polyposis colorectal cancer (HNPCC) according to the revised Bethesda

guidelines?

A. Colorectal cancer in a patient aged less than 50 years

B. Presence of synchronous colorectal cancer regardless of age

C. Colorectal cancer with MSI histology regardless of age

D. Colorectal cancer diagnosed in two or more first-degree relatives with

HNPCC-related tumor regardless of age

Question 12.14. Which of the following does NOT represent an HNPCC-related tumor?

A. Gastric cancer

B. Carcinoma of the small bowel

C. Pancreatic cancer

D. Breast cancer

Question 12.15. Which of the following malignancies are associated with germ line muta-

tions in theRETprotooncogene?

A. Multiple endocrine neoplasia (MEN) 2A

B. MEN 2B

C. Sporadic medullary thyroid carcinoma

D. All the above