Devita, Hellman, and Rosenberg's Cancer

LWBK1006-25 LWW-Govindan-Review December 12, 2011 19:21

356 DeVita, Hellman, and Rosenberg’s CANCER: Principles and Practice of Oncology Review

Question 25.31. All of the following are true about pheochromocytoma, EXCEPT:

A. It arises from the adrenal medulla in 50% of the cases.

B. Most tumors of adrenal origin are not malignant.

C. Extra-adrenal tumors have increased risk of malignancy.

D. It may be associated with mutated RET proto-oncogene.

Question 25.32. All of the following statements are true regarding mitotane, EXCEPT:

A. It treats metastatic adrenocortical carcinoma.

B. It has significant gastrointestinal and neurological side effects.

C. It can improve hormonal production.

D. Mitotane levels should be monitored.

E. Overall survival benefit has been confirmed.

Question 25.33. All of the following statements are true regarding insulinoma, EXCEPT:

A. Whipple’s triad consists of symptoms of hypoglycemia when blood

glucose decreases and relief of symptoms with correction of glucose

levels.

B. It is frequently malignant.

C. Surgery is indicated in most cases.

D. MEN1 should be suspected.

Question 25.34. Excessive secretion of all the following will lead to diarrhea, EXCEPT:

A. Gastrin

B. Serum vasoactive intestinal peptide

C. 5-Hydroxy indole acetic acid

D. Insulin

Question 25.35. All of the following are true regarding pancreatic endocrine tumors,

EXCEPT:

A. Classified as APUDomas.

B. Gastrinoma is the least malignant.

C. Malignancy is established by the presence of metastasis.

D. Glucagonoma arises from alpha cells.

E. Insulinoma arises from beta cells.

Question 25.36. All of the following are true regarding papillary thyroid carcinoma

EXCEPT:

A. More common in women.

B. Follicular variant papillary thyroid carcinoma carries a worse prog-

nosis.

C. Orphan Annie eye nuclei are characteristic feature of papillary thy-

roid carcinoma.

D. Median age at diagnosis is about 40 years.