Devita, Hellman, and Rosenberg's Cancer

LWBK1006-26 LWW-Govindan-Review December 12, 2011 19:29

Chapter 26•Sarcomas 369

Question 26.20. A 16-year-old female patient presents with a painful rapidly growing

scapular mass. Core needle biopsy reveals a Ewing’s sarcoma. Staging

evaluation shows no evidence of metastatic disease. The most appropri-

ate therapy is:

A. Resection

B. Preoperative chemotherapy (with vincristine, doxorubicin, and

cyclophosphamide alternating with ifosfamide and etoposide, IE),

resection, and adjuvant chemotherapy

C. Resection and radiation

D. Preoperative chemotherapy (with vincristine, doxorubicin, and

cyclophosphamide), resection, and adjuvant chemotherapy

Question 26.21. A 25-year-old woman presents with a painless right thigh mass, which

has been slowly growing over a span of 8 years. Core needle biopsy

reveals alveolar soft part sarcoma. What cytogenetic abnormality would

you expect to see in this tumor?

A. t(11,22) (q24;q12)

B. t(12;16) (q13;p11)

C. der (17)t(X;17) (p11;q25)

D. t(X;18) (p11,q11)

Question 26.22. Which of the following targeted agents is used to treat alveolar soft tissue

sarcoma?

A. Imatinib

B. Sunitinib

C. Dasatinib

D. Nilotinib

Question 26.23. Which of the following sites of soft tissue sarcomas carries the best prog-

nosis?

A. Head and neck

B. Extremity

C. Visceral

D. Retroperitoneal