Devita, Hellman, and Rosenberg's Cancer

LWBK1006-02 LWW-Govindan-Review November 24, 2011 11:18

32 DeVita, Hellman, and Rosenberg’s CANCER: Principles and Practice of Oncology Review

Answer 2.43. The answer is A.

In the stochastic model of tumor heterogeneity, every cell within the tumor

has equal potential but low probability of initiating tumor growth.

Answer 2.44. The answer is B.

The hierarchy model of tumor heterogeneity hypothesizes the existence

of functionally distinct classes of cells within the tumor, and only those

with unique self-renewal ability produce new tumor growth.

Answer 2.45. The answer is B.

PLX4032 is an orally available inhibitor of the mutatedBRAFgene. It

has shown activity in patients with malignant melanoma that carry the

BRAF V600E mutation. About 60% of all patients with melanomas have

the V600E BRAF mutation.

Answer 2.46. The answer is D.

Pemetrexed is a folate antimetabolite that targets enzymes involved in

purine and pyrimidine synthesis. 5-Fluorouracil is an antimetabolite

that targets thymidylate synthase. Temsirolimus is mammalian target of

rapamycin (mTOR) inhibitor that targets the PI3-kinase pathway. The

PI3-kinase pathway is involved in regulation of glucose metabolism.