Devita, Hellman, and Rosenberg's Cancer

LWBK1006-38 LWW-Govindan-Review December 12, 2011 20:29

498 DeVita, Hellman, and Rosenberg’s CANCER: Principles and Practice of Oncology Review

Question 38.4. Which of the following is true about the combination of rituximab with

chemotherapy for AIDS-associated lymphomas?

A. Adding rituximab to cyclophosphamide, doxorubicin, vincristine,

and prednisone (CHOP) chemotherapy in patients with CD4

<50/mm^3 may result in higher rate of neutropenic infections.

B. Rituximab is of no added benefit to CHOP or infusional etopo-

side, vincristine, and doxorubicin, bolus cyclophosphamide, and

daily prednisone (EPOCH) chemotherapy for AIDS-associated dif-

fuse large B cell lymphoma (DLBCL).

C. Rituximab with chemotherapy is usually beneficial in plasmablastic

lymphoma.

D. Rituximab with chemotherapy is usually beneficial in primary effu-

sion lymphoma.

Question 38.5. Which is NOT true concerning primary central nervous system (CNS)

lymphoma in AIDS?

A. Positive cerebrospinal fluid (CSF) Epstein-Barr virus (EBV) poly-

merase chain reaction (PCR) test, a consistent radiological picture,

and brain biopsy are necessary to diagnose primary CNS AIDS lym-

phoma.

B. In patients with CD4 count<50/mm^3 and poor performance status,

cranial radiotherapy alone may be appropriate.

C. In patients with CD4 count>50/mm^3 and good performance status,

the use of high-dose methotrexate with leucovorin rescue may be

appropriate.

D. Addition of HAART may increase the duration of response.

Question 38.6. A 38-year-old man with HIV infection presents with 3-month history of

weight loss and night sweats. He is not on antiretroviral therapy and his

last CD4 count 3 months ago was 300/mm^3. On exam, he has multiple

enlarged cervical lymph nodes. His hemoglobin is 10 g/dL, white blood

cell count is 3.6 K/cumm, and platelet count is 190 K/cumm. Serum LDH

is 300. Infectious workup is negative. CT of the neck and chest demon-

strates diffuse cervical and mediastinal lymphadenopathy. You suspect

lymphoma and arrange for an excisional biopsy of a neck lymph node.

Which of the following lymphomas is a non-AIDS defining cancer?

A. Hodgkin disease

B. DLBCL

C. Burkitt lymphoma

D. Primary CNS lymphoma

Question 38.7. Which of the following statements is correct regarding KS?

A. Tumor, node, metastasis (TNM) system is useful for staging KS.

B. Extent of tumor and AIDS-related systemic illnesses is useful in strat-

ifying patients with KS into prognostic risk groups.

C. Response Evaluation Criteria in Solid Tumors (RECIST) is useful in

assessing KS response to therapy.

D. All of the above are correct.