LWBK1006-41 LWW-Govindan-Review November 24, 2011 11:29
CHAPTER 41 PARANEOPLASTIC
SYNDROMES
C. DANIEL KINGSLEY•MICHAEL C. PERRY
DIRECTIONS Each of the numbered items below is followed by lettered answers. Select the
ONE lettered answer that is BEST in each case unless instructed otherwise.
QUESTIONS
Question 41.1. Chronic lymphocytic leukemia (CLL) has been associated with all of the
following, EXCEPT:
A. Pure red cell aplasia
B. Warm antibody hemolytic anemia
C. Microangiopathic hemolytic anemia
D. Paraneoplastic pemphigus
Question 41.2. Which of the statements about small cell lung cancer (SCLC) is FALSE?
A. SCLC is the second leading cause of ectopic adrenocorticotropic hor-
mone (ACTH) production after bronchial carcinoid.
B. SCLC is the leading cause of syndrome of inappropriate antidiuretic
hormone production (SIADH).
C. Subacute sensory neuronopathy and encephalomyeloneuritis is most
frequently associated with SCLC, compared with other forms of
cancer.
D. Patients with cancer with Lambert-Eaton syndrome (LES) most fre-
quently have SCLC as an underlying cause.
Question 41.3. Ectopic ACTH production causes all the following, EXCEPT:
A. Muscle wasting
B. Moon facies
C. Hypokalemia
D. Hyperpigmentation
Question 41.4. Many patients with SCLC produce ectopic ACTH, but what percentage
develop clinical Cushing’s syndrome?
A. 3% to 7%
B. 12% to 15%
C. 20% to 25%
D. 33% to 36%
Corresponding Chapter inCancer: Principles & Practice of Oncology,Ninth Edition: 153 (Paraneoplastic Syn-
dromes).
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