Devita, Hellman, and Rosenberg's Cancer

LWBK1006-03 LWW-Govindan-Review November 24, 2011 11:19

Chapter 3•Etiology of Cancer Part 1 39

Question 3.30. Association between HCV and HCC includes the following, EXCEPT:

A. Alcohol consumption or coinfection with hepatitis B virus (HBV) in

a patient with HCV increases the risk of HCC.

B. Treatment of patients with HCV with interferon and ribavirin elimi-

nates the risk of HCC in these patients.

C. There is a 20- to 30-year lag period between HCV infection and the

development of HCC.

D. Inflammatory changes resulting from HCV infection are primarily

responsible for development of HCC in HCV-infected patients.

Question 3.31. HBV has the following characteristics, EXCEPT:

A. DNA virus that belongs to the hepadnavirus family.

B. In 95% of individuals who become infected with HBV, the infection

resolves with clearance of the virus.

C. Twenty-five percent of individuals infected with HBV develop HCC.

D. HBV-infected patients who develop chronic hepatitis are at an

increased risk of developing HCC.

Question 3.32. Human papilloma virus (HPV) has been linked with the following cancers,

EXCEPT:

A. Cervical cancer

B. Penile cancer

C. Oropharyngeal cancers

D. Esophageal cancers

Question 3.33. Pathogenesis of cervical cancer from HPV infection is characterized by

the following, EXCEPT:

A. E6 and E7 viral proteins are most closely related to the transforming

potential of HPV.

B. Every person infected with HPV eventually develops cancer.

C. Smoking is identified as a risk factor and can increase the risk of

cervical cancer in HPV-infected patients.

D. Cell-cycle regulatory proteins p53 and RB (retinoblastoma protein)

are important targets of HPV oncoproteins.

Question 3.34. The following type of HPV has a strong association with cervical cancer:

A. HPV-6

B. HPV-11

C. HPV-16

D. None of the above