LWBK1006-03 LWW-Govindan-Review November 24, 2011 11:19
Chapter 3•Etiology of Cancer Part 1 41Question 3.40. Which of the following sentences best describes immune surveillance of
tumors?
A. Innate immunity has no effective role in immune surveillance of
tumors.
B. A standard mechanism of immune surveillance is involved for all
tumors.
C. Immune surveillance of tumors is based on expression of appropriate
tumor antigens.
D. Both innate and adaptive immune cells, along with their effector
molecules, are important in immune surveillance of tumors.Question 3.41. All the following statements are true regarding immune surveillance of
tumors, EXCEPT:
A. The presence of tumor-infiltrating lymphocytes in tumors, such as
colon and ovarian cancer, is associated with improved prognosis.
B. In patients with paraneoplastic neurologic syndromes, the autoim-
mune response also controls tumor progression.
C. Among the skin cancers, melanoma risk is increased the most in
immune-suppressed individuals.
D. Acute infections with bacteria could induce regressions of cancers.Question 3.42. Evidence that supports the association of inflammation and cancer include
the following, EXCEPT:
A. An ulcerative lesion resulting from chronic inflammation after skin
thermal injury can undergo malignant transformation.
B. Inflammatory cells are frequently present in tumor stroma.
C. Changes induced by acute bronchitis can lead to lung cancer.
D. Risk of colon cancer is increased in patients with inflammatory bowel
disease.Question 3.43. Infectious agents can cause cancers by:
A. Transformation of infected cells
B. Establishing a chronic inflammatory microenvironment in the
infected tissues
C. None of the above
D. Both A and BQuestion 3.44. All statements regarding tumor necrosis factor (TNF) and cancer are true,
EXCEPT:
A. TNF can induce apoptosis of tumor and endothelial cells.
B. TNF can induce production of matrix metalloproteinase (MMP)-9
and activation of nuclear factor (NF)-kB.
C. TNF can promote carcinogenesis.
D. None of the above.